Diagnosis of Catecholaminergic Polymorphic Ventricular Tachycardia

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is primary electrical heart disease characterized by development of polymorphic, including bidirectional, ventricular tachycardia in response to adrenergic stimulation caused by physical or emotional stress. The major CPVT’s clinical manif...

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Main Authors: Ekaterina K. Kulbachinskaya, Vera V. Bereznitskaya
Format: Article
Language:English
Published: "Paediatrician" Publishers LLC 2024-09-01
Series:Вопросы современной педиатрии
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Online Access:https://vsp.spr-journal.ru/jour/article/view/3564
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author Ekaterina K. Kulbachinskaya
Vera V. Bereznitskaya
author_facet Ekaterina K. Kulbachinskaya
Vera V. Bereznitskaya
author_sort Ekaterina K. Kulbachinskaya
collection DOAJ
description Catecholaminergic polymorphic ventricular tachycardia (CPVT) is primary electrical heart disease characterized by development of polymorphic, including bidirectional, ventricular tachycardia in response to adrenergic stimulation caused by physical or emotional stress. The major CPVT’s clinical manifestation is faintness caused by exercises, emotional stress, or beta-adrenergic agonists administration. This disease has high mortality rate without any treatment. The difficulties of preclinical diagnosis as well as late diagnosis after CPVT’s clinical signs manifestation dictate the need to analyze and systematize all the data on disease’s causes, clinical manifestations, and existing diagnostic approaches. This work has particular focus on the analysis of the disease molecular genetic causes and the spectrum of associated disorders in patients with CPVT regarding its diagnosis, management, and prognosis. Future research topics were determined for improving diagnosis quality and reducing mortality of patients with CPVT.
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institution Kabale University
issn 1682-5527
1682-5535
language English
publishDate 2024-09-01
publisher "Paediatrician" Publishers LLC
record_format Article
series Вопросы современной педиатрии
spelling doaj-art-bda1e29337d14c2197971df96efb742c2025-08-20T03:34:41Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352024-09-0123421321910.15690/vsp.v23i4.27732181Diagnosis of Catecholaminergic Polymorphic Ventricular TachycardiaEkaterina K. Kulbachinskaya0Vera V. Bereznitskaya1Pirogov Russian National Research Medical UniversityPirogov Russian National Research Medical UniversityCatecholaminergic polymorphic ventricular tachycardia (CPVT) is primary electrical heart disease characterized by development of polymorphic, including bidirectional, ventricular tachycardia in response to adrenergic stimulation caused by physical or emotional stress. The major CPVT’s clinical manifestation is faintness caused by exercises, emotional stress, or beta-adrenergic agonists administration. This disease has high mortality rate without any treatment. The difficulties of preclinical diagnosis as well as late diagnosis after CPVT’s clinical signs manifestation dictate the need to analyze and systematize all the data on disease’s causes, clinical manifestations, and existing diagnostic approaches. This work has particular focus on the analysis of the disease molecular genetic causes and the spectrum of associated disorders in patients with CPVT regarding its diagnosis, management, and prognosis. Future research topics were determined for improving diagnosis quality and reducing mortality of patients with CPVT.https://vsp.spr-journal.ru/jour/article/view/3564catecholaminergic polymorphic ventricular tachycardiaryr2 genecasq2 geneprimary channelopathiessudden cardiac death
spellingShingle Ekaterina K. Kulbachinskaya
Vera V. Bereznitskaya
Diagnosis of Catecholaminergic Polymorphic Ventricular Tachycardia
Вопросы современной педиатрии
catecholaminergic polymorphic ventricular tachycardia
ryr2 gene
casq2 gene
primary channelopathies
sudden cardiac death
title Diagnosis of Catecholaminergic Polymorphic Ventricular Tachycardia
title_full Diagnosis of Catecholaminergic Polymorphic Ventricular Tachycardia
title_fullStr Diagnosis of Catecholaminergic Polymorphic Ventricular Tachycardia
title_full_unstemmed Diagnosis of Catecholaminergic Polymorphic Ventricular Tachycardia
title_short Diagnosis of Catecholaminergic Polymorphic Ventricular Tachycardia
title_sort diagnosis of catecholaminergic polymorphic ventricular tachycardia
topic catecholaminergic polymorphic ventricular tachycardia
ryr2 gene
casq2 gene
primary channelopathies
sudden cardiac death
url https://vsp.spr-journal.ru/jour/article/view/3564
work_keys_str_mv AT ekaterinakkulbachinskaya diagnosisofcatecholaminergicpolymorphicventriculartachycardia
AT veravbereznitskaya diagnosisofcatecholaminergicpolymorphicventriculartachycardia