Gender-specific associations of metabolic and circadian syndromes with melanoma risk: insights from NHANES 2007–2018
Abstract Melanoma incidence is increasing worldwide, prompting exploration into novel risk factors beyond traditional exposures like ultraviolet radiation. Recent studies suggest that metabolic and circadian disruptions may also contribute to melanoma development, yet their influence is poorly under...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-08-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-15461-3 |
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| author | Yiru Chen Chang Liu Zhenghao Wang Weikun Qi Feng Niu |
| author_facet | Yiru Chen Chang Liu Zhenghao Wang Weikun Qi Feng Niu |
| author_sort | Yiru Chen |
| collection | DOAJ |
| description | Abstract Melanoma incidence is increasing worldwide, prompting exploration into novel risk factors beyond traditional exposures like ultraviolet radiation. Recent studies suggest that metabolic and circadian disruptions may also contribute to melanoma development, yet their influence is poorly understood. This study examines the relationships between metabolic syndrome (MetS), circadian syndrome (CircS) and melanoma risk, emphasizing differences between different genders. Using National Health and Nutrition Examination Survey (NHANES) data (2007–2018), this cross-sectional study applied logistic regression to assess MetS and CircS associations with melanoma risk, adjusting for demographic and lifestyle factors. Receiver operating characteristic curves evaluated predictive ability, and restricted cubic spline models examined dose-response patterns. Among 29,132 participants, 209 reported a melanoma diagnosis. Individuals with MetS or CircS showed a higher melanoma risk. Analysis by gender revealed stronger associations in males than in females. In males, melanoma risk rose sharply when more than two MetS components were present, indicating a dose-response pattern. Additionally, the triglyceride glucose index levels showed more notable predictive value in females than males. MetS and CircS are associated with a higher melanoma risk, with a greater effect of MetS components in males. These findings highlight the potential relevance of metabolic and circadian health in understanding melanoma risk patterns. |
| format | Article |
| id | doaj-art-bd8e26e637b64167aa4de6cac18477dd |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-bd8e26e637b64167aa4de6cac18477dd2025-08-24T11:25:01ZengNature PortfolioScientific Reports2045-23222025-08-0115111410.1038/s41598-025-15461-3Gender-specific associations of metabolic and circadian syndromes with melanoma risk: insights from NHANES 2007–2018Yiru Chen0Chang Liu1Zhenghao Wang2Weikun Qi3Feng Niu4Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegePlastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegePlastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegePlastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegePlastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAbstract Melanoma incidence is increasing worldwide, prompting exploration into novel risk factors beyond traditional exposures like ultraviolet radiation. Recent studies suggest that metabolic and circadian disruptions may also contribute to melanoma development, yet their influence is poorly understood. This study examines the relationships between metabolic syndrome (MetS), circadian syndrome (CircS) and melanoma risk, emphasizing differences between different genders. Using National Health and Nutrition Examination Survey (NHANES) data (2007–2018), this cross-sectional study applied logistic regression to assess MetS and CircS associations with melanoma risk, adjusting for demographic and lifestyle factors. Receiver operating characteristic curves evaluated predictive ability, and restricted cubic spline models examined dose-response patterns. Among 29,132 participants, 209 reported a melanoma diagnosis. Individuals with MetS or CircS showed a higher melanoma risk. Analysis by gender revealed stronger associations in males than in females. In males, melanoma risk rose sharply when more than two MetS components were present, indicating a dose-response pattern. Additionally, the triglyceride glucose index levels showed more notable predictive value in females than males. MetS and CircS are associated with a higher melanoma risk, with a greater effect of MetS components in males. These findings highlight the potential relevance of metabolic and circadian health in understanding melanoma risk patterns.https://doi.org/10.1038/s41598-025-15461-3MelanomaMetabolic syndromeCircadian syndromeTriglyceride glucose index |
| spellingShingle | Yiru Chen Chang Liu Zhenghao Wang Weikun Qi Feng Niu Gender-specific associations of metabolic and circadian syndromes with melanoma risk: insights from NHANES 2007–2018 Scientific Reports Melanoma Metabolic syndrome Circadian syndrome Triglyceride glucose index |
| title | Gender-specific associations of metabolic and circadian syndromes with melanoma risk: insights from NHANES 2007–2018 |
| title_full | Gender-specific associations of metabolic and circadian syndromes with melanoma risk: insights from NHANES 2007–2018 |
| title_fullStr | Gender-specific associations of metabolic and circadian syndromes with melanoma risk: insights from NHANES 2007–2018 |
| title_full_unstemmed | Gender-specific associations of metabolic and circadian syndromes with melanoma risk: insights from NHANES 2007–2018 |
| title_short | Gender-specific associations of metabolic and circadian syndromes with melanoma risk: insights from NHANES 2007–2018 |
| title_sort | gender specific associations of metabolic and circadian syndromes with melanoma risk insights from nhanes 2007 2018 |
| topic | Melanoma Metabolic syndrome Circadian syndrome Triglyceride glucose index |
| url | https://doi.org/10.1038/s41598-025-15461-3 |
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