AAV-mediated co-expression of an immunogenic transgene plus PD-L1 enables sustained expression through immunological evasion

AAV-mediated co-expression of an immunogenic transgene plus PD-L1 enables sustained expression through immunological evasion

Abstract Adeno-associated virus (AAV) vectors can mediate long-term expression of immunogenic transgenes in vivo through transduction of tolerogenic cells in the liver. Tissue-targeted AAV vectors allow transduction of non-hepatic cells, but this necessitates development of strategies to minimize tr...

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Bibliographic Details
Main Authors: Travis B. McMurphy, Andrew Park, Patrick J. Heizer, Crystal Bottenfield, James H. Kurasawa, Yasuhiro Ikeda, Michael R. Doran
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Adeno-associated virus
Immunogenicity
PD-L1
Transgene
Gene therapy
Online Access:https://doi.org/10.1038/s41598-024-75698-2
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