Soluble triggering receptor expressed on myeloid cells 1 is associated with hemoconcentration and endothelial activation in children and young adults with dengue virus infection in the Philippines.
<h4>Background</h4>Triggering receptor expressed on myeloid cells 1 (TREM1) is a cell-surface receptor expressed on neutrophils that amplifies the inflammatory response. Dengue virus (DENV) infection is characterized by systemic inflammation, endothelial activation, and vascular leakage....
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-06-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0013084 |
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| author | Jiayi Yang Hridesh Mishra Michelle Ngai Vanessa Tran Maria Salome Siose Painaga James Yared Gaite Ashley Roberts Kevin C Kain Michael T Hawkes |
| author_facet | Jiayi Yang Hridesh Mishra Michelle Ngai Vanessa Tran Maria Salome Siose Painaga James Yared Gaite Ashley Roberts Kevin C Kain Michael T Hawkes |
| author_sort | Jiayi Yang |
| collection | DOAJ |
| description | <h4>Background</h4>Triggering receptor expressed on myeloid cells 1 (TREM1) is a cell-surface receptor expressed on neutrophils that amplifies the inflammatory response. Dengue virus (DENV) infection is characterized by systemic inflammation, endothelial activation, and vascular leakage.<h4>Methodology/principal findings</h4>We investigated circulating soluble TREM-1 (sTREM-1) levels in 244 children and young adults aged 1-26 years with dengue fever presenting to an outpatient clinic in the Philippines. Elevated sTREM-1 (≥130 pg/mL) was associated with hemoconcentration, a hallmark of vascular leakage (odds ratio (OR) 3.8, 95%CI 1.6-10, p = 0.0020). In turn, hemoconcentration was associated with hospitalization (OR 4.2, 95%CI 1.0-38, p = 0.0497) and higher volume of intravenous fluid required for resuscitation (p = 0.019). Elevated inflammation marker TNF (≥5 pg/mL) was associated with increased sTREM-1 levels (p = 0.0014). Endothelial activation markers angiopoietin-2 (Ang-2), soluble FMS-like tyrosine kinase-1 (sFlt-1), and soluble vascular cell adhesion molecule 1 (sVCAM-1) were correlated with sTREM-1 levels (p < 0.0001 for all three comparisons).<h4>Conclusions/significance</h4>Our findings suggest that sTREM-1 may be a clinically informative marker of neutrophil activation, associated with hemoconcentration, systemic inflammation, and endothelial activation and in dengue fever. |
| format | Article |
| id | doaj-art-bd7faf299c624cc1b2ae99078cb2895c |
| institution | DOAJ |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-bd7faf299c624cc1b2ae99078cb2895c2025-08-20T03:16:18ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352025-06-01196e001308410.1371/journal.pntd.0013084Soluble triggering receptor expressed on myeloid cells 1 is associated with hemoconcentration and endothelial activation in children and young adults with dengue virus infection in the Philippines.Jiayi YangHridesh MishraMichelle NgaiVanessa TranMaria Salome Siose PainagaJames Yared GaiteAshley RobertsKevin C KainMichael T Hawkes<h4>Background</h4>Triggering receptor expressed on myeloid cells 1 (TREM1) is a cell-surface receptor expressed on neutrophils that amplifies the inflammatory response. Dengue virus (DENV) infection is characterized by systemic inflammation, endothelial activation, and vascular leakage.<h4>Methodology/principal findings</h4>We investigated circulating soluble TREM-1 (sTREM-1) levels in 244 children and young adults aged 1-26 years with dengue fever presenting to an outpatient clinic in the Philippines. Elevated sTREM-1 (≥130 pg/mL) was associated with hemoconcentration, a hallmark of vascular leakage (odds ratio (OR) 3.8, 95%CI 1.6-10, p = 0.0020). In turn, hemoconcentration was associated with hospitalization (OR 4.2, 95%CI 1.0-38, p = 0.0497) and higher volume of intravenous fluid required for resuscitation (p = 0.019). Elevated inflammation marker TNF (≥5 pg/mL) was associated with increased sTREM-1 levels (p = 0.0014). Endothelial activation markers angiopoietin-2 (Ang-2), soluble FMS-like tyrosine kinase-1 (sFlt-1), and soluble vascular cell adhesion molecule 1 (sVCAM-1) were correlated with sTREM-1 levels (p < 0.0001 for all three comparisons).<h4>Conclusions/significance</h4>Our findings suggest that sTREM-1 may be a clinically informative marker of neutrophil activation, associated with hemoconcentration, systemic inflammation, and endothelial activation and in dengue fever.https://doi.org/10.1371/journal.pntd.0013084 |
| spellingShingle | Jiayi Yang Hridesh Mishra Michelle Ngai Vanessa Tran Maria Salome Siose Painaga James Yared Gaite Ashley Roberts Kevin C Kain Michael T Hawkes Soluble triggering receptor expressed on myeloid cells 1 is associated with hemoconcentration and endothelial activation in children and young adults with dengue virus infection in the Philippines. PLoS Neglected Tropical Diseases |
| title | Soluble triggering receptor expressed on myeloid cells 1 is associated with hemoconcentration and endothelial activation in children and young adults with dengue virus infection in the Philippines. |
| title_full | Soluble triggering receptor expressed on myeloid cells 1 is associated with hemoconcentration and endothelial activation in children and young adults with dengue virus infection in the Philippines. |
| title_fullStr | Soluble triggering receptor expressed on myeloid cells 1 is associated with hemoconcentration and endothelial activation in children and young adults with dengue virus infection in the Philippines. |
| title_full_unstemmed | Soluble triggering receptor expressed on myeloid cells 1 is associated with hemoconcentration and endothelial activation in children and young adults with dengue virus infection in the Philippines. |
| title_short | Soluble triggering receptor expressed on myeloid cells 1 is associated with hemoconcentration and endothelial activation in children and young adults with dengue virus infection in the Philippines. |
| title_sort | soluble triggering receptor expressed on myeloid cells 1 is associated with hemoconcentration and endothelial activation in children and young adults with dengue virus infection in the philippines |
| url | https://doi.org/10.1371/journal.pntd.0013084 |
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