Effects of exercise training on prostate cancer: Current evidence and potential molecular mechanisms
Prostate cancer (PCa) is a significant health concern globally, being the most diagnosed cancer and the second leading cause of male mortality in the United States. Despite advances in treatment, exploring non-treatment approaches to improve the health outcomes of patients with PCa is crucial. Exerc...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-09-01
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| Series: | Advanced Exercise and Health Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950273X24000547 |
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| author | Madison Webber Muqing Li Changmeng Cai Kai Zou |
| author_facet | Madison Webber Muqing Li Changmeng Cai Kai Zou |
| author_sort | Madison Webber |
| collection | DOAJ |
| description | Prostate cancer (PCa) is a significant health concern globally, being the most diagnosed cancer and the second leading cause of male mortality in the United States. Despite advances in treatment, exploring non-treatment approaches to improve the health outcomes of patients with PCa is crucial. Exercise has emerged as a promising strategy, with evidence suggesting its efficacy in reducing cancer severity, inhibiting tumor progression and metastasis, and promoting less aggressive cancer phenotypes. Observational studies have highlighted a positive association between increased physical activity levels and reduced PCa-specific mortality and disease progression. However, the molecular mechanisms underlying exercise-induced benefits against PCa tumor growth and progression remain poorly understood. Therefore, the purpose of this review is to summarize the pre-clinical and clinical evidence of exercise-induced beneficial effects on PCa tumor growth and outline potential molecular mechanisms by which exercise training attenuates tumor growth and progression. By elucidating the therapeutic potential and molecular mechanisms of exercise training in managing PCa tumor growth, this review aims to inspire further research in this field and offer insights for developing novel therapies that target the molecular alterations with exercise training to treat PCa. It is worth noting that due to the lack of human clinical studies investigating molecular mechanisms responsible for PCa tumor growth, the majority of the data reviewed here is from preclinical models. |
| format | Article |
| id | doaj-art-bd7e2817253f447dbd9042f74b1da54e |
| institution | DOAJ |
| issn | 2950-273X |
| language | English |
| publishDate | 2024-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Advanced Exercise and Health Science |
| spelling | doaj-art-bd7e2817253f447dbd9042f74b1da54e2025-08-20T03:21:12ZengKeAi Communications Co., Ltd.Advanced Exercise and Health Science2950-273X2024-09-011316016910.1016/j.aehs.2024.08.003Effects of exercise training on prostate cancer: Current evidence and potential molecular mechanismsMadison Webber0Muqing Li1Changmeng Cai2Kai Zou3School of Science and Health, Emmanuel College, Boston, MA, USA; Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USADepartment of Biology, College of Science and Mathematics, University of Massachusetts Boston, Boston, MA, USA; Center for Personalized Cancer Therapy, University of Massachusetts Boston, Boston, MA, USADepartment of Biology, College of Science and Mathematics, University of Massachusetts Boston, Boston, MA, USA; Center for Personalized Cancer Therapy, University of Massachusetts Boston, Boston, MA, USADepartment of Exercise and Health Sciences, College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA, USA; Correspondence to: Department of Exercise and Health Sciences, University of Massachusetts Boston, Boston, MA, USA.Prostate cancer (PCa) is a significant health concern globally, being the most diagnosed cancer and the second leading cause of male mortality in the United States. Despite advances in treatment, exploring non-treatment approaches to improve the health outcomes of patients with PCa is crucial. Exercise has emerged as a promising strategy, with evidence suggesting its efficacy in reducing cancer severity, inhibiting tumor progression and metastasis, and promoting less aggressive cancer phenotypes. Observational studies have highlighted a positive association between increased physical activity levels and reduced PCa-specific mortality and disease progression. However, the molecular mechanisms underlying exercise-induced benefits against PCa tumor growth and progression remain poorly understood. Therefore, the purpose of this review is to summarize the pre-clinical and clinical evidence of exercise-induced beneficial effects on PCa tumor growth and outline potential molecular mechanisms by which exercise training attenuates tumor growth and progression. By elucidating the therapeutic potential and molecular mechanisms of exercise training in managing PCa tumor growth, this review aims to inspire further research in this field and offer insights for developing novel therapies that target the molecular alterations with exercise training to treat PCa. It is worth noting that due to the lack of human clinical studies investigating molecular mechanisms responsible for PCa tumor growth, the majority of the data reviewed here is from preclinical models.http://www.sciencedirect.com/science/article/pii/S2950273X24000547ExerciseMouse ModelsPhysical ActivityMyokineOxidative StressAngiogenesis |
| spellingShingle | Madison Webber Muqing Li Changmeng Cai Kai Zou Effects of exercise training on prostate cancer: Current evidence and potential molecular mechanisms Advanced Exercise and Health Science Exercise Mouse Models Physical Activity Myokine Oxidative Stress Angiogenesis |
| title | Effects of exercise training on prostate cancer: Current evidence and potential molecular mechanisms |
| title_full | Effects of exercise training on prostate cancer: Current evidence and potential molecular mechanisms |
| title_fullStr | Effects of exercise training on prostate cancer: Current evidence and potential molecular mechanisms |
| title_full_unstemmed | Effects of exercise training on prostate cancer: Current evidence and potential molecular mechanisms |
| title_short | Effects of exercise training on prostate cancer: Current evidence and potential molecular mechanisms |
| title_sort | effects of exercise training on prostate cancer current evidence and potential molecular mechanisms |
| topic | Exercise Mouse Models Physical Activity Myokine Oxidative Stress Angiogenesis |
| url | http://www.sciencedirect.com/science/article/pii/S2950273X24000547 |
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