Effects of prebiotics, probiotics and synbiotics on serum creatinine in non-dialysis patients: a meta-analysis of randomized controlled trials
Objective Serum creatinine level are influenced by many factors. Although accumulated data suggested that prebiotics, probiotics and synbiotics supplements could affect serum creatinine level, the results remained controversial. The aim of the present paper was to evaluate the effects of prebiotics,...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2022.2152693 |
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| _version_ | 1850040515537403904 |
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| author | Fenfen Liu Yang Liu Xueai Lv Hengzhong Lun |
| author_facet | Fenfen Liu Yang Liu Xueai Lv Hengzhong Lun |
| author_sort | Fenfen Liu |
| collection | DOAJ |
| description | Objective Serum creatinine level are influenced by many factors. Although accumulated data suggested that prebiotics, probiotics and synbiotics supplements could affect serum creatinine level, the results remained controversial. The aim of the present paper was to evaluate the effects of prebiotics, probiotics and synbiotics on serum creatinine in non-dialysis patients.Methods PubMed, EMBASE (Excerpta Medica Database) and the Cochrane Library databases were searched for eligible randomized, controlled trials (RCTs) which were limited to English language studies until 30 September 2022. A random-effects model was performed to analyze the impact of pooled trials.Result Twelve randomized, controlled trial studies were included in the meta-analysis. Prebiotics, probiotics or synbiotics supplementation did not significantly decrease the serum creatinine levels in non-dialysis patients compared to placebo [standardized mean difference (SMD) = 0.05; 95% confidence interval (CI): (−0.21, 0.31); p = 0.72; I2 = 61%].Conclusion The present meta-analysis indicated that supplementation with prebiotics, probiotics and synbiotics could not act as promising adjuvant therapies to decrease the serum creatinine levels in non-dialysis patients. |
| format | Article |
| id | doaj-art-bd7d5d531ec34cb6ac9dc4ca514161c0 |
| institution | DOAJ |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-bd7d5d531ec34cb6ac9dc4ca514161c02025-08-20T02:56:05ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145110.1080/0886022X.2022.2152693Effects of prebiotics, probiotics and synbiotics on serum creatinine in non-dialysis patients: a meta-analysis of randomized controlled trialsFenfen Liu0Yang Liu1Xueai Lv2Hengzhong Lun3Department of Nephrology, The Affiliated Taian City Central Hospital of Qingdao University, Taian, ChinaSenior Department of Cardiology, the Sixth Medical Center, Chinese PLA General Hospital, Beijing, ChinaDepartment of Nephrology, The Affiliated Taian City Central Hospital of Qingdao University, Taian, ChinaDepartment of Clinical Laboratory, The Affiliated Taian City Central Hospital of Qingdao University, Taian, ChinaObjective Serum creatinine level are influenced by many factors. Although accumulated data suggested that prebiotics, probiotics and synbiotics supplements could affect serum creatinine level, the results remained controversial. The aim of the present paper was to evaluate the effects of prebiotics, probiotics and synbiotics on serum creatinine in non-dialysis patients.Methods PubMed, EMBASE (Excerpta Medica Database) and the Cochrane Library databases were searched for eligible randomized, controlled trials (RCTs) which were limited to English language studies until 30 September 2022. A random-effects model was performed to analyze the impact of pooled trials.Result Twelve randomized, controlled trial studies were included in the meta-analysis. Prebiotics, probiotics or synbiotics supplementation did not significantly decrease the serum creatinine levels in non-dialysis patients compared to placebo [standardized mean difference (SMD) = 0.05; 95% confidence interval (CI): (−0.21, 0.31); p = 0.72; I2 = 61%].Conclusion The present meta-analysis indicated that supplementation with prebiotics, probiotics and synbiotics could not act as promising adjuvant therapies to decrease the serum creatinine levels in non-dialysis patients.https://www.tandfonline.com/doi/10.1080/0886022X.2022.2152693Chronic kidney diseasemeta-analysisprebioticsprobioticssynbioticscreatinine |
| spellingShingle | Fenfen Liu Yang Liu Xueai Lv Hengzhong Lun Effects of prebiotics, probiotics and synbiotics on serum creatinine in non-dialysis patients: a meta-analysis of randomized controlled trials Renal Failure Chronic kidney disease meta-analysis prebiotics probiotics synbiotics creatinine |
| title | Effects of prebiotics, probiotics and synbiotics on serum creatinine in non-dialysis patients: a meta-analysis of randomized controlled trials |
| title_full | Effects of prebiotics, probiotics and synbiotics on serum creatinine in non-dialysis patients: a meta-analysis of randomized controlled trials |
| title_fullStr | Effects of prebiotics, probiotics and synbiotics on serum creatinine in non-dialysis patients: a meta-analysis of randomized controlled trials |
| title_full_unstemmed | Effects of prebiotics, probiotics and synbiotics on serum creatinine in non-dialysis patients: a meta-analysis of randomized controlled trials |
| title_short | Effects of prebiotics, probiotics and synbiotics on serum creatinine in non-dialysis patients: a meta-analysis of randomized controlled trials |
| title_sort | effects of prebiotics probiotics and synbiotics on serum creatinine in non dialysis patients a meta analysis of randomized controlled trials |
| topic | Chronic kidney disease meta-analysis prebiotics probiotics synbiotics creatinine |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2022.2152693 |
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