Role of Neuroinflammation in Adult Neurogenesis and Alzheimer Disease: Therapeutic Approaches
Neuroinflammation, a specialized immune response that takes place in the central nervous system, has been linked to neurodegenerative diseases, and specially, it has been considered as a hallmark of Alzheimer disease, the most common cause of dementia in the elderly nowadays. Furthermore, neuroinfla...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/260925 |
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| _version_ | 1832548915454410752 |
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| author | Almudena Fuster-Matanzo María Llorens-Martín Félix Hernández Jesús Avila |
| author_facet | Almudena Fuster-Matanzo María Llorens-Martín Félix Hernández Jesús Avila |
| author_sort | Almudena Fuster-Matanzo |
| collection | DOAJ |
| description | Neuroinflammation, a specialized immune response that takes place in the central nervous system, has been linked to neurodegenerative diseases, and specially, it has been considered as a hallmark of Alzheimer disease, the most common cause of dementia in the elderly nowadays. Furthermore, neuroinflammation has been demonstrated to affect important processes in the brain, such as the formation of new neurons, commonly known as adult neurogenesis. For this, many therapeutic approaches have been developed in order to avoid or mitigate the deleterious effects caused by the chronic activation of the immune response. Considering this, in this paper we revise the relationships between neuroinflammation, Alzheimer disease, and adult neurogenesis, as well as the current therapeutic approaches that have been developed in the field. |
| format | Article |
| id | doaj-art-bd74a30c65914a058a5b1476f1d8748c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-bd74a30c65914a058a5b1476f1d8748c2025-02-03T06:12:40ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/260925260925Role of Neuroinflammation in Adult Neurogenesis and Alzheimer Disease: Therapeutic ApproachesAlmudena Fuster-Matanzo0María Llorens-Martín1Félix Hernández2Jesús Avila3Department of Molecular Neurobiology, Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, SpainDepartment of Molecular Neurobiology, Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, SpainDepartment of Molecular Neurobiology, Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, SpainDepartment of Molecular Neurobiology, Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, SpainNeuroinflammation, a specialized immune response that takes place in the central nervous system, has been linked to neurodegenerative diseases, and specially, it has been considered as a hallmark of Alzheimer disease, the most common cause of dementia in the elderly nowadays. Furthermore, neuroinflammation has been demonstrated to affect important processes in the brain, such as the formation of new neurons, commonly known as adult neurogenesis. For this, many therapeutic approaches have been developed in order to avoid or mitigate the deleterious effects caused by the chronic activation of the immune response. Considering this, in this paper we revise the relationships between neuroinflammation, Alzheimer disease, and adult neurogenesis, as well as the current therapeutic approaches that have been developed in the field.http://dx.doi.org/10.1155/2013/260925 |
| spellingShingle | Almudena Fuster-Matanzo María Llorens-Martín Félix Hernández Jesús Avila Role of Neuroinflammation in Adult Neurogenesis and Alzheimer Disease: Therapeutic Approaches Mediators of Inflammation |
| title | Role of Neuroinflammation in Adult Neurogenesis and Alzheimer Disease: Therapeutic Approaches |
| title_full | Role of Neuroinflammation in Adult Neurogenesis and Alzheimer Disease: Therapeutic Approaches |
| title_fullStr | Role of Neuroinflammation in Adult Neurogenesis and Alzheimer Disease: Therapeutic Approaches |
| title_full_unstemmed | Role of Neuroinflammation in Adult Neurogenesis and Alzheimer Disease: Therapeutic Approaches |
| title_short | Role of Neuroinflammation in Adult Neurogenesis and Alzheimer Disease: Therapeutic Approaches |
| title_sort | role of neuroinflammation in adult neurogenesis and alzheimer disease therapeutic approaches |
| url | http://dx.doi.org/10.1155/2013/260925 |
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