Complete coding region sequence analyses and antigenic characterization of emerging lineage G-IX of foot- and-mouth disease virus serotype Asia1
Foot-and-mouth disease Virus (FMDV) serotype Asia1 is prevalent in the Indian subcontinent, with only G-III and G-VIII reported in India until 2020. However, in 2019, a novel genetic group within serotype Asia1, designated as G-IX, emerged in Bangladesh, followed by its detection in India in 2020. T...
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Taylor & Francis Group
2024-12-01
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| Series: | Veterinary Quarterly |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/01652176.2024.2367215 |
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| author | Manoranjan Rout Shyam Singh Dahiya Saravanan Subramaniam Ramakant Acharya Reshama Samanta Jitendra Kumar Biswal Jajati Keshari Mohapatra Rabindra Prasad Singh |
| author_facet | Manoranjan Rout Shyam Singh Dahiya Saravanan Subramaniam Ramakant Acharya Reshama Samanta Jitendra Kumar Biswal Jajati Keshari Mohapatra Rabindra Prasad Singh |
| author_sort | Manoranjan Rout |
| collection | DOAJ |
| description | Foot-and-mouth disease Virus (FMDV) serotype Asia1 is prevalent in the Indian subcontinent, with only G-III and G-VIII reported in India until 2020. However, in 2019, a novel genetic group within serotype Asia1, designated as G-IX, emerged in Bangladesh, followed by its detection in India in 2020. This report presents analyses of the complete coding region sequences of the G-IX lineage isolates. The length of the open reading frame (ORF) of the two G-IX isolates was 6990 nucleotides without any deletion or insertion. The G-IX isolates showed the highest sequence similarity with an isolate of G-III at the ORF, L, P2, and P3 regions, and with an isolate of G-VIII at the P1 region. Phylogenetic analysis based on the capsid region (P1) supports the hypothesis that G-VIII and G-IX originated from a common ancestor, as speculated earlier. Further, VP1 region-based phylogenetic analyses revealed the re-emergence of G-VIII after a gap of 3 years. One isolate of G-VIII collected during 2023 revealed a codon insertion in the G-H loop of VP1. The vaccine matching studies support the suitability of the currently used Indian vaccine strain IND63/1972 to contain outbreaks due to viruses belonging to G-IX. |
| format | Article |
| id | doaj-art-bd6fca15f0ac4bb7a3bcaf5456dd005b |
| institution | DOAJ |
| issn | 0165-2176 1875-5941 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Veterinary Quarterly |
| spelling | doaj-art-bd6fca15f0ac4bb7a3bcaf5456dd005b2025-08-20T02:50:37ZengTaylor & Francis GroupVeterinary Quarterly0165-21761875-59412024-12-0144111010.1080/01652176.2024.2367215Complete coding region sequence analyses and antigenic characterization of emerging lineage G-IX of foot- and-mouth disease virus serotype Asia1Manoranjan Rout0Shyam Singh Dahiya1Saravanan Subramaniam2Ramakant Acharya3Reshama Samanta4Jitendra Kumar Biswal5Jajati Keshari Mohapatra6Rabindra Prasad Singh7International Centre for Foot and Mouth Disease, ICAR-National Institute on Foot and Mouth Disease, Bhubaneswar, IndiaInternational Centre for Foot and Mouth Disease, ICAR-National Institute on Foot and Mouth Disease, Bhubaneswar, IndiaInternational Centre for Foot and Mouth Disease, ICAR-National Institute on Foot and Mouth Disease, Bhubaneswar, IndiaInternational Centre for Foot and Mouth Disease, ICAR-National Institute on Foot and Mouth Disease, Bhubaneswar, IndiaInternational Centre for Foot and Mouth Disease, ICAR-National Institute on Foot and Mouth Disease, Bhubaneswar, IndiaInternational Centre for Foot and Mouth Disease, ICAR-National Institute on Foot and Mouth Disease, Bhubaneswar, IndiaInternational Centre for Foot and Mouth Disease, ICAR-National Institute on Foot and Mouth Disease, Bhubaneswar, IndiaInternational Centre for Foot and Mouth Disease, ICAR-National Institute on Foot and Mouth Disease, Bhubaneswar, IndiaFoot-and-mouth disease Virus (FMDV) serotype Asia1 is prevalent in the Indian subcontinent, with only G-III and G-VIII reported in India until 2020. However, in 2019, a novel genetic group within serotype Asia1, designated as G-IX, emerged in Bangladesh, followed by its detection in India in 2020. This report presents analyses of the complete coding region sequences of the G-IX lineage isolates. The length of the open reading frame (ORF) of the two G-IX isolates was 6990 nucleotides without any deletion or insertion. The G-IX isolates showed the highest sequence similarity with an isolate of G-III at the ORF, L, P2, and P3 regions, and with an isolate of G-VIII at the P1 region. Phylogenetic analysis based on the capsid region (P1) supports the hypothesis that G-VIII and G-IX originated from a common ancestor, as speculated earlier. Further, VP1 region-based phylogenetic analyses revealed the re-emergence of G-VIII after a gap of 3 years. One isolate of G-VIII collected during 2023 revealed a codon insertion in the G-H loop of VP1. The vaccine matching studies support the suitability of the currently used Indian vaccine strain IND63/1972 to contain outbreaks due to viruses belonging to G-IX.https://www.tandfonline.com/doi/10.1080/01652176.2024.2367215Foot and mouth disease virusserotype Asia 1group-IXIndiavaccine strainEmergence |
| spellingShingle | Manoranjan Rout Shyam Singh Dahiya Saravanan Subramaniam Ramakant Acharya Reshama Samanta Jitendra Kumar Biswal Jajati Keshari Mohapatra Rabindra Prasad Singh Complete coding region sequence analyses and antigenic characterization of emerging lineage G-IX of foot- and-mouth disease virus serotype Asia1 Veterinary Quarterly Foot and mouth disease virus serotype Asia 1 group-IX India vaccine strain Emergence |
| title | Complete coding region sequence analyses and antigenic characterization of emerging lineage G-IX of foot- and-mouth disease virus serotype Asia1 |
| title_full | Complete coding region sequence analyses and antigenic characterization of emerging lineage G-IX of foot- and-mouth disease virus serotype Asia1 |
| title_fullStr | Complete coding region sequence analyses and antigenic characterization of emerging lineage G-IX of foot- and-mouth disease virus serotype Asia1 |
| title_full_unstemmed | Complete coding region sequence analyses and antigenic characterization of emerging lineage G-IX of foot- and-mouth disease virus serotype Asia1 |
| title_short | Complete coding region sequence analyses and antigenic characterization of emerging lineage G-IX of foot- and-mouth disease virus serotype Asia1 |
| title_sort | complete coding region sequence analyses and antigenic characterization of emerging lineage g ix of foot and mouth disease virus serotype asia1 |
| topic | Foot and mouth disease virus serotype Asia 1 group-IX India vaccine strain Emergence |
| url | https://www.tandfonline.com/doi/10.1080/01652176.2024.2367215 |
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