Lycium barbarum L.: a potential botanical drug for preventing and treating retinal cell apoptosis
Retinal cell apoptosis is the primary pathological process in many retinal diseases, including retinitis pigmentosa and age-related macular degeneration, which can cause severe visual impairment and blindness. Lycium barbarum L., a traditional Chinese medicinal botanical drug, has a long history and...
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| Format: | Article |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1571554/full |
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| author | Meng Xiong Meng Xiong Meng Xiong Jun Peng Shunhua Zhou Shunhua Zhou Shunhua Zhou Qing Gao Qing Gao Qing Gao Jing Lu Jing Lu Chen Ou Houpan Song Houpan Song Houpan Song Qinghua Peng Qinghua Peng Qinghua Peng |
| author_facet | Meng Xiong Meng Xiong Meng Xiong Jun Peng Shunhua Zhou Shunhua Zhou Shunhua Zhou Qing Gao Qing Gao Qing Gao Jing Lu Jing Lu Chen Ou Houpan Song Houpan Song Houpan Song Qinghua Peng Qinghua Peng Qinghua Peng |
| author_sort | Meng Xiong |
| collection | DOAJ |
| description | Retinal cell apoptosis is the primary pathological process in many retinal diseases, including retinitis pigmentosa and age-related macular degeneration, which can cause severe visual impairment and blindness. Lycium barbarum L., a traditional Chinese medicinal botanical drug, has a long history and extensive application in ophthalmic disease prevention and treatment. This study systematically reviewed the key active metabolites in L. barbarum L., including L. barbarum polysaccharides, carotenoids, and flavonoids, that exert retinal protective effects. A comprehensive analysis of the pharmacological effects and underlying molecular mechanisms of L. barbarum L. and its active metabolites in the prevention and treatment of retinal cell apoptosis, including essential aspects such as antioxidant activity, anti-inflammatory properties, autophagy regulation, and mitochondrial function preservation, is essential to establish a comprehensive and solid theoretical basis for further investigation of the medicinal value of L. barbarum L. in ophthalmology and provide a reference for future research directions. |
| format | Article |
| id | doaj-art-bd6dbd3b01154728bb7189fa3a9daf21 |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-bd6dbd3b01154728bb7189fa3a9daf212025-08-20T01:49:28ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-03-011610.3389/fphar.2025.15715541571554Lycium barbarum L.: a potential botanical drug for preventing and treating retinal cell apoptosisMeng Xiong0Meng Xiong1Meng Xiong2Jun Peng3Shunhua Zhou4Shunhua Zhou5Shunhua Zhou6Qing Gao7Qing Gao8Qing Gao9Jing Lu10Jing Lu11Chen Ou12Houpan Song13Houpan Song14Houpan Song15Qinghua Peng16Qinghua Peng17Qinghua Peng18Hunan Provincial Key Laboratory of Traditional Chinese Medicine Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaSchool of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaHunan Provincial Key Laboratory for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha, Hunan, ChinaHunan Provincial Key Laboratory of Traditional Chinese Medicine Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaSchool of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaHunan Provincial Key Laboratory for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaHunan Provincial Key Laboratory of Traditional Chinese Medicine Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaSchool of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaHunan Provincial Key Laboratory for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaHunan Provincial Key Laboratory for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaSchool of Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaDepartment of Ophthalmology, The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha, Hunan, ChinaHunan Provincial Key Laboratory of Traditional Chinese Medicine Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaSchool of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaHunan Provincial Key Laboratory for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaHunan Provincial Key Laboratory of Traditional Chinese Medicine Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaSchool of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaHunan Provincial Key Laboratory for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaRetinal cell apoptosis is the primary pathological process in many retinal diseases, including retinitis pigmentosa and age-related macular degeneration, which can cause severe visual impairment and blindness. Lycium barbarum L., a traditional Chinese medicinal botanical drug, has a long history and extensive application in ophthalmic disease prevention and treatment. This study systematically reviewed the key active metabolites in L. barbarum L., including L. barbarum polysaccharides, carotenoids, and flavonoids, that exert retinal protective effects. A comprehensive analysis of the pharmacological effects and underlying molecular mechanisms of L. barbarum L. and its active metabolites in the prevention and treatment of retinal cell apoptosis, including essential aspects such as antioxidant activity, anti-inflammatory properties, autophagy regulation, and mitochondrial function preservation, is essential to establish a comprehensive and solid theoretical basis for further investigation of the medicinal value of L. barbarum L. in ophthalmology and provide a reference for future research directions.https://www.frontiersin.org/articles/10.3389/fphar.2025.1571554/fullLycium barbarum L.retinal cellsapoptosisretinitis pigmentosaagerelated macular degeneration |
| spellingShingle | Meng Xiong Meng Xiong Meng Xiong Jun Peng Shunhua Zhou Shunhua Zhou Shunhua Zhou Qing Gao Qing Gao Qing Gao Jing Lu Jing Lu Chen Ou Houpan Song Houpan Song Houpan Song Qinghua Peng Qinghua Peng Qinghua Peng Lycium barbarum L.: a potential botanical drug for preventing and treating retinal cell apoptosis Frontiers in Pharmacology Lycium barbarum L. retinal cells apoptosis retinitis pigmentosa agerelated macular degeneration |
| title | Lycium barbarum L.: a potential botanical drug for preventing and treating retinal cell apoptosis |
| title_full | Lycium barbarum L.: a potential botanical drug for preventing and treating retinal cell apoptosis |
| title_fullStr | Lycium barbarum L.: a potential botanical drug for preventing and treating retinal cell apoptosis |
| title_full_unstemmed | Lycium barbarum L.: a potential botanical drug for preventing and treating retinal cell apoptosis |
| title_short | Lycium barbarum L.: a potential botanical drug for preventing and treating retinal cell apoptosis |
| title_sort | lycium barbarum l a potential botanical drug for preventing and treating retinal cell apoptosis |
| topic | Lycium barbarum L. retinal cells apoptosis retinitis pigmentosa agerelated macular degeneration |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1571554/full |
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