Simultaneous co-delivery of Ginsenoside Rg3 and imiquimod from PLGA nanoparticles for effective breast cancer immunotherapy
Summary: Breast cancer is a fatal malignancy facing human health, with most patients experiencing recurrence and resistance to chemotherapy. The immunosuppressive tumor microenvironment (TME) greatly limits the actual outcome of immunotherapy. This study aimed to develop a modality of theranostics n...
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Elsevier
2025-05-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225005358 |
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| author | Cong Hu Shuxiong Nong Qianqian Ke Ziming Wu Yuancheng Jiang Ying Wang Yixin Chen Ziling Wu Qi Zhang Chilin Liao Meng Wu |
| author_facet | Cong Hu Shuxiong Nong Qianqian Ke Ziming Wu Yuancheng Jiang Ying Wang Yixin Chen Ziling Wu Qi Zhang Chilin Liao Meng Wu |
| author_sort | Cong Hu |
| collection | DOAJ |
| description | Summary: Breast cancer is a fatal malignancy facing human health, with most patients experiencing recurrence and resistance to chemotherapy. The immunosuppressive tumor microenvironment (TME) greatly limits the actual outcome of immunotherapy. This study aimed to develop a modality of theranostics nanoparticles for breast cancer based on a near-infrared light-triggered nanoparticle for the targeted delivery of ginsenoside Rg3 and immune adjuvants imiquimod (R837) for effective breast cancer immunotherapy. Folate-receptor (FA) targeting IR780-R837/ginsenoside Rg3-perfluorohexane (PFH) @ polyethylene glycol (PEG)—poly (lactide-co-glycolic acid) (PLGA) nanoparticles (FA-NPs) can be activated by near-infrared laser irradiation in tumors, which leads to rapid release of ginsenoside Rg3 and R837 in the regions with high expression of folate receptors and glucose transporter 1 (GLUT1). Meanwhile, the nanoparticles can be used as dual-mode contrast agents for photoacoustic and ultrasound imaging. This strategy provides a strong immune memory effect, which can prevent tumor recurrence after eliminating the initial tumor. |
| format | Article |
| id | doaj-art-bd6576fd85604b4789746d7e598e2bbf |
| institution | OA Journals |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-bd6576fd85604b4789746d7e598e2bbf2025-08-20T02:09:26ZengElsevieriScience2589-00422025-05-0128511227410.1016/j.isci.2025.112274Simultaneous co-delivery of Ginsenoside Rg3 and imiquimod from PLGA nanoparticles for effective breast cancer immunotherapyCong Hu0Shuxiong Nong1Qianqian Ke2Ziming Wu3Yuancheng Jiang4Ying Wang5Yixin Chen6Ziling Wu7Qi Zhang8Chilin Liao9Meng Wu10Department of Ultrasound, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, ChinaDepartment of Cardiology, Baise People’s Hospital. Affiliated Southwest Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi, ChinaDepartment of Ultrasound, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, ChinaSchool of Public Health, Southeast University, Nanjing 210009, Jiangsu, ChinaDepartment of Ultrasound, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, ChinaDepartment of Ultrasound, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, ChinaDepartment of Ultrasound, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, ChinaDepartment of Ultrasound, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, ChinaDepartment of Ultrasound, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, ChinaDepartment of Cardiology, Baise People’s Hospital. Affiliated Southwest Hospital of Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China; Corresponding authorDepartment of Ultrasound, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, China; Corresponding authorSummary: Breast cancer is a fatal malignancy facing human health, with most patients experiencing recurrence and resistance to chemotherapy. The immunosuppressive tumor microenvironment (TME) greatly limits the actual outcome of immunotherapy. This study aimed to develop a modality of theranostics nanoparticles for breast cancer based on a near-infrared light-triggered nanoparticle for the targeted delivery of ginsenoside Rg3 and immune adjuvants imiquimod (R837) for effective breast cancer immunotherapy. Folate-receptor (FA) targeting IR780-R837/ginsenoside Rg3-perfluorohexane (PFH) @ polyethylene glycol (PEG)—poly (lactide-co-glycolic acid) (PLGA) nanoparticles (FA-NPs) can be activated by near-infrared laser irradiation in tumors, which leads to rapid release of ginsenoside Rg3 and R837 in the regions with high expression of folate receptors and glucose transporter 1 (GLUT1). Meanwhile, the nanoparticles can be used as dual-mode contrast agents for photoacoustic and ultrasound imaging. This strategy provides a strong immune memory effect, which can prevent tumor recurrence after eliminating the initial tumor.http://www.sciencedirect.com/science/article/pii/S2589004225005358Drug delivery systemCancerBiomaterialsNanomaterials |
| spellingShingle | Cong Hu Shuxiong Nong Qianqian Ke Ziming Wu Yuancheng Jiang Ying Wang Yixin Chen Ziling Wu Qi Zhang Chilin Liao Meng Wu Simultaneous co-delivery of Ginsenoside Rg3 and imiquimod from PLGA nanoparticles for effective breast cancer immunotherapy iScience Drug delivery system Cancer Biomaterials Nanomaterials |
| title | Simultaneous co-delivery of Ginsenoside Rg3 and imiquimod from PLGA nanoparticles for effective breast cancer immunotherapy |
| title_full | Simultaneous co-delivery of Ginsenoside Rg3 and imiquimod from PLGA nanoparticles for effective breast cancer immunotherapy |
| title_fullStr | Simultaneous co-delivery of Ginsenoside Rg3 and imiquimod from PLGA nanoparticles for effective breast cancer immunotherapy |
| title_full_unstemmed | Simultaneous co-delivery of Ginsenoside Rg3 and imiquimod from PLGA nanoparticles for effective breast cancer immunotherapy |
| title_short | Simultaneous co-delivery of Ginsenoside Rg3 and imiquimod from PLGA nanoparticles for effective breast cancer immunotherapy |
| title_sort | simultaneous co delivery of ginsenoside rg3 and imiquimod from plga nanoparticles for effective breast cancer immunotherapy |
| topic | Drug delivery system Cancer Biomaterials Nanomaterials |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225005358 |
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