An affinity-modulated T cell engager targeting Claudin 18.2 shows potent anti-tumor activity with limited cytokine release

An affinity-modulated T cell engager targeting Claudin 18.2 shows potent anti-tumor activity with limited cytokine release

Background AZD5863 is a bispecific T cell engager (TCE) with high affinity to CLDN18.2 and low affinity to cluster of differentiation 3 (CD3), designed to decrease its peripheral cytokine release potential, improve the therapeutic index, and maintain potent anti-tumor activity.Methods AZD5863 was ev...

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Bibliographic Details
Main Authors: D Gareth Rees, Yun He, Scott A Hammond, Mark Cobbold, Nicolas Giraldo, Saso Cemerski, Marina Natoli, Yiping Rong, Jonathan Fitzgerald, Kathy Mulgrew, Simon J Dovedi, Miguel Gaspar, Christopher Lloyd, Jim Eyles, Laure Castan, Sharif Rahmy, Cathryn Kelton, Martin Korade, Oisin Huhn, Anna Sigurdardottir, Kathryn Ball, Laura Dallaway, Jonathan J Taylor, Phillip M Brailey, Aleksandra Toloczko, Maria A S Broggi, Andrew Kunihiro, Sudhanshu Abhishek
Format: Article
Language:English
Published: BMJ Publishing Group 2025-08-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/8/e011857.full
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