IGF-1 c.258 A > G synonymous mutation ameliorates senile osteoporosis
Abstract Senile osteoporosis (SOP) is a multifactorial, age-related progressive phenomenon with a considerable morbidity and mortality. IGF-1 is an important regulator of bone reconstruction and metabolism throughout life. Nevertheless, our previous study unexpectedly found there is no change in the...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-07369-x |
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| author | Zhaoguo Wang Dayou Dai Siyao Wang Libo Zhang Yi Li Xunming Zhang Yunyun Cheng Linlin Hao |
| author_facet | Zhaoguo Wang Dayou Dai Siyao Wang Libo Zhang Yi Li Xunming Zhang Yunyun Cheng Linlin Hao |
| author_sort | Zhaoguo Wang |
| collection | DOAJ |
| description | Abstract Senile osteoporosis (SOP) is a multifactorial, age-related progressive phenomenon with a considerable morbidity and mortality. IGF-1 is an important regulator of bone reconstruction and metabolism throughout life. Nevertheless, our previous study unexpectedly found there is no change in the peak bone mass with a altered IGF-1 gene expression leaded by IGF-1 c.258 A > G synonymous mutation. Considering its involvement in the cellular senescence, we suspected c.258 A > G may participate in SOP. Therefore, the effect of IGF-1 c.258 A > G on SOP was firstly detected, the changes of bone formation and bone resorption index in SOP mice with two genotypes indicated it improved SOP. Then, the in vitro study confirmed the mutation ameliorates SOP by promoting the growth and development of senescent osteoblasts. At last, co-culture of osteoblast and osteoclast further verified the mutation prevents SOP by increasing the bone formation capacity of senescent osteoblasts. Collectively, this study illuminated the role of IGF-1 c.258 A > G in ameliorating SOP. |
| format | Article |
| id | doaj-art-bd634e8d26994e07837e2b91639b9166 |
| institution | DOAJ |
| issn | 2399-3642 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-bd634e8d26994e07837e2b91639b91662025-08-20T02:39:41ZengNature PortfolioCommunications Biology2399-36422024-12-017111110.1038/s42003-024-07369-xIGF-1 c.258 A > G synonymous mutation ameliorates senile osteoporosisZhaoguo Wang0Dayou Dai1Siyao Wang2Libo Zhang3Yi Li4Xunming Zhang5Yunyun Cheng6Linlin Hao7College of Animal Science, Jilin UniversityState Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Ren Ji Hospital, School of medicine, Shanghai Jiao Tong UniversityCollege of Animal Science, Jilin UniversityCollege of Animal Science, Jilin UniversityCollege of Animal Science, Jilin UniversityCollege of Animal Science, Jilin UniversityCollege of Animal Science, Jilin UniversityCollege of Animal Science, Jilin UniversityAbstract Senile osteoporosis (SOP) is a multifactorial, age-related progressive phenomenon with a considerable morbidity and mortality. IGF-1 is an important regulator of bone reconstruction and metabolism throughout life. Nevertheless, our previous study unexpectedly found there is no change in the peak bone mass with a altered IGF-1 gene expression leaded by IGF-1 c.258 A > G synonymous mutation. Considering its involvement in the cellular senescence, we suspected c.258 A > G may participate in SOP. Therefore, the effect of IGF-1 c.258 A > G on SOP was firstly detected, the changes of bone formation and bone resorption index in SOP mice with two genotypes indicated it improved SOP. Then, the in vitro study confirmed the mutation ameliorates SOP by promoting the growth and development of senescent osteoblasts. At last, co-culture of osteoblast and osteoclast further verified the mutation prevents SOP by increasing the bone formation capacity of senescent osteoblasts. Collectively, this study illuminated the role of IGF-1 c.258 A > G in ameliorating SOP.https://doi.org/10.1038/s42003-024-07369-x |
| spellingShingle | Zhaoguo Wang Dayou Dai Siyao Wang Libo Zhang Yi Li Xunming Zhang Yunyun Cheng Linlin Hao IGF-1 c.258 A > G synonymous mutation ameliorates senile osteoporosis Communications Biology |
| title | IGF-1 c.258 A > G synonymous mutation ameliorates senile osteoporosis |
| title_full | IGF-1 c.258 A > G synonymous mutation ameliorates senile osteoporosis |
| title_fullStr | IGF-1 c.258 A > G synonymous mutation ameliorates senile osteoporosis |
| title_full_unstemmed | IGF-1 c.258 A > G synonymous mutation ameliorates senile osteoporosis |
| title_short | IGF-1 c.258 A > G synonymous mutation ameliorates senile osteoporosis |
| title_sort | igf 1 c 258 a g synonymous mutation ameliorates senile osteoporosis |
| url | https://doi.org/10.1038/s42003-024-07369-x |
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