Integrating single-cell RNA-seq and bulk RNA-seq to construct a neutrophil prognostic model for predicting prognosis and immune response in oral squamous cell carcinoma

Integrating single-cell RNA-seq and bulk RNA-seq to construct a neutrophil prognostic model for predicting prognosis and immune response in oral squamous cell carcinoma

Abstract Background Oral squamous cell carcinoma (OSCC) is an aggressive malignancy with poor prognosis. Neutrophil infiltration has been associated with unfavorable outcomes in OSCC, but the underlying molecular mechanisms remain unclear. Methods This study integrated single-cell transcriptomics (s...

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Bibliographic Details
Main Authors: Jinhang Wang, Zifeng Cui, Qiwen Song, Kaicheng Yang, Yanping Chen, Shixiong Peng
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Human Genomics
Subjects:
Oral squamous cell carcinoma
Neutrophils
Immune landscape
Risk model
Biomarkers
Online Access:https://doi.org/10.1186/s40246-024-00712-7
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