Therapeutic Potential of a Vasopressin V2 Receptor Antagonist for Calcium Channel Blocker-Associated Edema with Vasospastic Angina
Calcium channel blocker- (CCB-) associated peripheral edema does not resolve without CCB discontinuation or dose reduction. However, renin–angiotensin system (RAS) inhibitors have been reported to be effective for CCB-associated edema. We report a case of vasospastic angina with refractory CCB-assoc...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Cardiology |
| Online Access: | http://dx.doi.org/10.1155/2022/9550006 |
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| _version_ | 1850176701438361600 |
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| author | Kojiro Toda Masashi Fujino Kota Murai Teruo Noguchi |
| author_facet | Kojiro Toda Masashi Fujino Kota Murai Teruo Noguchi |
| author_sort | Kojiro Toda |
| collection | DOAJ |
| description | Calcium channel blocker- (CCB-) associated peripheral edema does not resolve without CCB discontinuation or dose reduction. However, renin–angiotensin system (RAS) inhibitors have been reported to be effective for CCB-associated edema. We report a case of vasospastic angina with refractory CCB-associated edema. A 78-year-old man had refractory edema induced by a CCB. It was successfully treated with tolvaptan, an active vasopressin V2 receptor antagonist. The aim of this case report is to understand the mechanism and treatment of CCB-associated peripheral edema and how tolvaptan affects peripheral edema. |
| format | Article |
| id | doaj-art-bd5f6ebdf9cf4456b638c8a46dd0860a |
| institution | OA Journals |
| issn | 2090-6412 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Cardiology |
| spelling | doaj-art-bd5f6ebdf9cf4456b638c8a46dd0860a2025-08-20T02:19:12ZengWileyCase Reports in Cardiology2090-64122022-01-01202210.1155/2022/9550006Therapeutic Potential of a Vasopressin V2 Receptor Antagonist for Calcium Channel Blocker-Associated Edema with Vasospastic AnginaKojiro Toda0Masashi Fujino1Kota Murai2Teruo Noguchi3Department of Cardiovascular MedicineDepartment of Cardiovascular MedicineDepartment of Cardiovascular MedicineDepartment of Cardiovascular MedicineCalcium channel blocker- (CCB-) associated peripheral edema does not resolve without CCB discontinuation or dose reduction. However, renin–angiotensin system (RAS) inhibitors have been reported to be effective for CCB-associated edema. We report a case of vasospastic angina with refractory CCB-associated edema. A 78-year-old man had refractory edema induced by a CCB. It was successfully treated with tolvaptan, an active vasopressin V2 receptor antagonist. The aim of this case report is to understand the mechanism and treatment of CCB-associated peripheral edema and how tolvaptan affects peripheral edema.http://dx.doi.org/10.1155/2022/9550006 |
| spellingShingle | Kojiro Toda Masashi Fujino Kota Murai Teruo Noguchi Therapeutic Potential of a Vasopressin V2 Receptor Antagonist for Calcium Channel Blocker-Associated Edema with Vasospastic Angina Case Reports in Cardiology |
| title | Therapeutic Potential of a Vasopressin V2 Receptor Antagonist for Calcium Channel Blocker-Associated Edema with Vasospastic Angina |
| title_full | Therapeutic Potential of a Vasopressin V2 Receptor Antagonist for Calcium Channel Blocker-Associated Edema with Vasospastic Angina |
| title_fullStr | Therapeutic Potential of a Vasopressin V2 Receptor Antagonist for Calcium Channel Blocker-Associated Edema with Vasospastic Angina |
| title_full_unstemmed | Therapeutic Potential of a Vasopressin V2 Receptor Antagonist for Calcium Channel Blocker-Associated Edema with Vasospastic Angina |
| title_short | Therapeutic Potential of a Vasopressin V2 Receptor Antagonist for Calcium Channel Blocker-Associated Edema with Vasospastic Angina |
| title_sort | therapeutic potential of a vasopressin v2 receptor antagonist for calcium channel blocker associated edema with vasospastic angina |
| url | http://dx.doi.org/10.1155/2022/9550006 |
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