Persistent miller fisher syndrome following COVID-19 infection: A case report
Guillain-Barré syndrome (GBS) is an inflammatory disease of the peripheral nervous system, with Miller-Fisher syndrome (MFS) being a rare variant. Recent studies have shown GBS and MFS to be a common side effect of COVID-19. This case report highlights the clinical presentation of a patient diagnose...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Journal of Family Medicine and Primary Care |
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| Online Access: | https://journals.lww.com/10.4103/jfmpc.jfmpc_504_24 |
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| author | Margaret Donat Ivie Odiase Aldo Alleva Aditya A. Bissoonauth Hamnah Khan Sara Siddiqui |
| author_facet | Margaret Donat Ivie Odiase Aldo Alleva Aditya A. Bissoonauth Hamnah Khan Sara Siddiqui |
| author_sort | Margaret Donat |
| collection | DOAJ |
| description | Guillain-Barré syndrome (GBS) is an inflammatory disease of the peripheral nervous system, with Miller-Fisher syndrome (MFS) being a rare variant. Recent studies have shown GBS and MFS to be a common side effect of COVID-19. This case report highlights the clinical presentation of a patient diagnosed with post-COVID-19 MFS, their subsequent treatment challenges, and the prognostic outcomes, contributing to the limited scientific literature of this uncommon affliction. A comprehensive case report of a 57-year-old man with significant medical history was conducted to determine the appropriate diagnosis based on the perceived symptoms following COVID-19. Per the Northwell health human research protection program, the publication of case reports involving up to three patients is not considered human-subject research and does not require IRB review and approval. Our patient was diagnosed with MFS, making him the longest-known adult with COVID-19-associated MFS without resolution of neurologic symptoms after intravenous immunoglobulin (IVIG) dose administration. Our case report posits the first-known patient to have a more severe form of MFS or resistance to IVIG dose. The current study also highlights the association between COVID-19 and MFS, warranting the need for more studies to understand the disease pathophysiology and new biomarkers for targeted treatments. |
| format | Article |
| id | doaj-art-bd5993a55b314f7dae88d282c9798ccf |
| institution | OA Journals |
| issn | 2249-4863 2278-7135 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj-art-bd5993a55b314f7dae88d282c9798ccf2025-08-20T02:02:55ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632278-71352025-05-011452070207310.4103/jfmpc.jfmpc_504_24Persistent miller fisher syndrome following COVID-19 infection: A case reportMargaret DonatIvie OdiaseAldo AllevaAditya A. BissoonauthHamnah KhanSara SiddiquiGuillain-Barré syndrome (GBS) is an inflammatory disease of the peripheral nervous system, with Miller-Fisher syndrome (MFS) being a rare variant. Recent studies have shown GBS and MFS to be a common side effect of COVID-19. This case report highlights the clinical presentation of a patient diagnosed with post-COVID-19 MFS, their subsequent treatment challenges, and the prognostic outcomes, contributing to the limited scientific literature of this uncommon affliction. A comprehensive case report of a 57-year-old man with significant medical history was conducted to determine the appropriate diagnosis based on the perceived symptoms following COVID-19. Per the Northwell health human research protection program, the publication of case reports involving up to three patients is not considered human-subject research and does not require IRB review and approval. Our patient was diagnosed with MFS, making him the longest-known adult with COVID-19-associated MFS without resolution of neurologic symptoms after intravenous immunoglobulin (IVIG) dose administration. Our case report posits the first-known patient to have a more severe form of MFS or resistance to IVIG dose. The current study also highlights the association between COVID-19 and MFS, warranting the need for more studies to understand the disease pathophysiology and new biomarkers for targeted treatments.https://journals.lww.com/10.4103/jfmpc.jfmpc_504_24case-based learningpatient-centered carephysical examination skillsprimary care issuesquality of carescreening |
| spellingShingle | Margaret Donat Ivie Odiase Aldo Alleva Aditya A. Bissoonauth Hamnah Khan Sara Siddiqui Persistent miller fisher syndrome following COVID-19 infection: A case report Journal of Family Medicine and Primary Care case-based learning patient-centered care physical examination skills primary care issues quality of care screening |
| title | Persistent miller fisher syndrome following COVID-19 infection: A case report |
| title_full | Persistent miller fisher syndrome following COVID-19 infection: A case report |
| title_fullStr | Persistent miller fisher syndrome following COVID-19 infection: A case report |
| title_full_unstemmed | Persistent miller fisher syndrome following COVID-19 infection: A case report |
| title_short | Persistent miller fisher syndrome following COVID-19 infection: A case report |
| title_sort | persistent miller fisher syndrome following covid 19 infection a case report |
| topic | case-based learning patient-centered care physical examination skills primary care issues quality of care screening |
| url | https://journals.lww.com/10.4103/jfmpc.jfmpc_504_24 |
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