Association of Pulse Prssure Index With Mortality in Patients With Hypertension: Results From NHANES 1999–2018
ABSTRACT Vascular compliance is an important predictor of cardiovascular disease and mortality. Pulse pressure index (PPI) is a reliable indicator for evaluating vascular compliance. However, the association between PPI, all‐cause mortality (ACM), and cardiovascular mortality (CVM) in patients with...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | The Journal of Clinical Hypertension |
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| Online Access: | https://doi.org/10.1111/jch.70004 |
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| author | Hongjin Jin Shusheng Fang Shuo An Yanchun Ding |
| author_facet | Hongjin Jin Shusheng Fang Shuo An Yanchun Ding |
| author_sort | Hongjin Jin |
| collection | DOAJ |
| description | ABSTRACT Vascular compliance is an important predictor of cardiovascular disease and mortality. Pulse pressure index (PPI) is a reliable indicator for evaluating vascular compliance. However, the association between PPI, all‐cause mortality (ACM), and cardiovascular mortality (CVM) in patients with hypertension is still unclear. In this study, we aimed to investigate the association of PPI with ACM and CVM in patients with hypertension. Kaplan–Meier survival curves, Cox proportional hazards regression models, restricted cubic splines, and subgroup and interaction analyses were used to investigate the association of PPI with ACM and CVM. U‐shaped associations were observed between PPI and both ACM and CVM, and the inflection points for ACM and CVM were at PPI values of 0.327 and 0.363, respectively. Time‐dependent receiver operating characteristic curves indicated that PPI showed good predictive value for both ACM and CVM occurrence at 1, 3, 5, and 10 years, and its predictive value was higher than PP for ACM and CVM at 5 and 10 years. These results showed that PPI can be used to identify patients with hypertension who are at a high risk of mortality and can guide more aggressive anti‐hypertensive treatment strategies. Moreover, these findings demonstrate that PPI is a superior vascular compliance indicator than PP. |
| format | Article |
| id | doaj-art-bd560795eadd4680ad4ce06a3bf64eb3 |
| institution | Kabale University |
| issn | 1524-6175 1751-7176 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | The Journal of Clinical Hypertension |
| spelling | doaj-art-bd560795eadd4680ad4ce06a3bf64eb32025-01-31T05:38:37ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762025-01-01271n/an/a10.1111/jch.70004Association of Pulse Prssure Index With Mortality in Patients With Hypertension: Results From NHANES 1999–2018Hongjin Jin0Shusheng Fang1Shuo An2Yanchun Ding3Department of Cardiology The Second Hospital of Dalian Medical University Dalian ChinaDepartment of Critical Care Medicine The Second Hospital of Dalian Medical University Dalian ChinaDepartment of Cardiology The Second Hospital of Dalian Medical University Dalian ChinaDepartment of Cardiology The Second Hospital of Dalian Medical University Dalian ChinaABSTRACT Vascular compliance is an important predictor of cardiovascular disease and mortality. Pulse pressure index (PPI) is a reliable indicator for evaluating vascular compliance. However, the association between PPI, all‐cause mortality (ACM), and cardiovascular mortality (CVM) in patients with hypertension is still unclear. In this study, we aimed to investigate the association of PPI with ACM and CVM in patients with hypertension. Kaplan–Meier survival curves, Cox proportional hazards regression models, restricted cubic splines, and subgroup and interaction analyses were used to investigate the association of PPI with ACM and CVM. U‐shaped associations were observed between PPI and both ACM and CVM, and the inflection points for ACM and CVM were at PPI values of 0.327 and 0.363, respectively. Time‐dependent receiver operating characteristic curves indicated that PPI showed good predictive value for both ACM and CVM occurrence at 1, 3, 5, and 10 years, and its predictive value was higher than PP for ACM and CVM at 5 and 10 years. These results showed that PPI can be used to identify patients with hypertension who are at a high risk of mortality and can guide more aggressive anti‐hypertensive treatment strategies. Moreover, these findings demonstrate that PPI is a superior vascular compliance indicator than PP.https://doi.org/10.1111/jch.70004pulse pressure indexpulse pressurehypertensionall‐cause mortalitycardiovascular mortality |
| spellingShingle | Hongjin Jin Shusheng Fang Shuo An Yanchun Ding Association of Pulse Prssure Index With Mortality in Patients With Hypertension: Results From NHANES 1999–2018 The Journal of Clinical Hypertension pulse pressure index pulse pressure hypertension all‐cause mortality cardiovascular mortality |
| title | Association of Pulse Prssure Index With Mortality in Patients With Hypertension: Results From NHANES 1999–2018 |
| title_full | Association of Pulse Prssure Index With Mortality in Patients With Hypertension: Results From NHANES 1999–2018 |
| title_fullStr | Association of Pulse Prssure Index With Mortality in Patients With Hypertension: Results From NHANES 1999–2018 |
| title_full_unstemmed | Association of Pulse Prssure Index With Mortality in Patients With Hypertension: Results From NHANES 1999–2018 |
| title_short | Association of Pulse Prssure Index With Mortality in Patients With Hypertension: Results From NHANES 1999–2018 |
| title_sort | association of pulse prssure index with mortality in patients with hypertension results from nhanes 1999 2018 |
| topic | pulse pressure index pulse pressure hypertension all‐cause mortality cardiovascular mortality |
| url | https://doi.org/10.1111/jch.70004 |
| work_keys_str_mv | AT hongjinjin associationofpulseprssureindexwithmortalityinpatientswithhypertensionresultsfromnhanes19992018 AT shushengfang associationofpulseprssureindexwithmortalityinpatientswithhypertensionresultsfromnhanes19992018 AT shuoan associationofpulseprssureindexwithmortalityinpatientswithhypertensionresultsfromnhanes19992018 AT yanchunding associationofpulseprssureindexwithmortalityinpatientswithhypertensionresultsfromnhanes19992018 |