Pre-clinical allergenicity assessment of IgE epitope-targeted Der p 2 mutants demonstrate potential as hypoallergenic AIT candidates

Pre-clinical allergenicity assessment of IgE epitope-targeted Der p 2 mutants demonstrate potential as hypoallergenic AIT candidates

BackgroundAdvancements in hybridoma technology have enabled the production of human IgE monoclonal antibodies (hIgE mAb) for successful IgE epitope mapping of major allergens. Here, we assessed the hypoallergenicity of three IgE-epitope mutants (single 4C8 or 2F10, and double 4C8 + 2F10 epitope muta...

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Main Authors: Glorismer Pena-Amelunxen, Mohadeseh Asghari, Kriti Khatri, Jill Glesner, Serge A. Versteeg, Ronald van Ree, Martin D. Chapman, Scott A. Smith, Maksymilian Chruszcz, Anna Pomés, Lorenz Aglas
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
allergen-specific immunotherapy
house dust mite
Der p 2
hypoallergenic
human IgE monoclonal antibodies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1623920/full
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