Erythrocytosis as an indicator of disease progression of small cell lung cancer: A case report
This case involves a 62-year-old male diagnosed with extensive-stage small cell lung cancer (ES-SCLC) originating from the right lower lobe with brain metastases. The patient underwent stereotactic radiosurgery (SRS) and received four cycles of combination therapy with cisplatin, etoposide, and durv...
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Elsevier
2025-01-01
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| Series: | Respiratory Medicine Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007125000760 |
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| author | Takuya Tanaka Yutaka Takahara Ryudai Abe Nagae Sumito Yoko Ishige Ikuyo Shionoya Kouichi Yamamura Masafumi Nojiri Masaharu Iguchi |
| author_facet | Takuya Tanaka Yutaka Takahara Ryudai Abe Nagae Sumito Yoko Ishige Ikuyo Shionoya Kouichi Yamamura Masafumi Nojiri Masaharu Iguchi |
| author_sort | Takuya Tanaka |
| collection | DOAJ |
| description | This case involves a 62-year-old male diagnosed with extensive-stage small cell lung cancer (ES-SCLC) originating from the right lower lobe with brain metastases. The patient underwent stereotactic radiosurgery (SRS) and received four cycles of combination therapy with cisplatin, etoposide, and durvalumab, followed by maintenance therapy with durvalumab to achieve disease control. On day 156 after treatment initiation, hemoglobin (Hb) levels increased to 16.9 g/dL, indicating polycythemia. Concurrently, new brain metastatic lesions were identified, and serum erythropoietin (EPO) levels were markedly elevated at 406 mIU/mL. Whole-brain radiation therapy (WBRT) was initiated, resulting in a subsequent reduction in hemoglobin levels and improvement in polycythemia. This report describes a rare case of secondary polycythemia associated with ES-SCLC. Notably, WBRT appeared to contribute to the normalization of serum EPO levels and resolution of polycythemia. This report elucidates the clinical course and relevance of this condition based on a literature review. |
| format | Article |
| id | doaj-art-bd4b22faacf8487f98ea945ef69109e2 |
| institution | Kabale University |
| issn | 2213-0071 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj-art-bd4b22faacf8487f98ea945ef69109e22025-08-20T03:31:30ZengElsevierRespiratory Medicine Case Reports2213-00712025-01-015610224010.1016/j.rmcr.2025.102240Erythrocytosis as an indicator of disease progression of small cell lung cancer: A case reportTakuya Tanaka0Yutaka Takahara1Ryudai Abe2Nagae Sumito3Yoko Ishige4Ikuyo Shionoya5Kouichi Yamamura6Masafumi Nojiri7Masaharu Iguchi8Department of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Kahoku-gun, Uchinada-machi, Ishikawa, 920-0293, JapanCorresponding author. Department of Respiratory Medicine, Kanazawa Medical University 1-1 Daigaku, Kahoku-gun, Uchinada-machi, Ishikawa, 920-0293, Japan.; Department of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Kahoku-gun, Uchinada-machi, Ishikawa, 920-0293, JapanDepartment of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Kahoku-gun, Uchinada-machi, Ishikawa, 920-0293, JapanDepartment of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Kahoku-gun, Uchinada-machi, Ishikawa, 920-0293, JapanDepartment of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Kahoku-gun, Uchinada-machi, Ishikawa, 920-0293, JapanDepartment of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Kahoku-gun, Uchinada-machi, Ishikawa, 920-0293, JapanDepartment of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Kahoku-gun, Uchinada-machi, Ishikawa, 920-0293, JapanDepartment of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Kahoku-gun, Uchinada-machi, Ishikawa, 920-0293, JapanDepartment of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku, Kahoku-gun, Uchinada-machi, Ishikawa, 920-0293, JapanThis case involves a 62-year-old male diagnosed with extensive-stage small cell lung cancer (ES-SCLC) originating from the right lower lobe with brain metastases. The patient underwent stereotactic radiosurgery (SRS) and received four cycles of combination therapy with cisplatin, etoposide, and durvalumab, followed by maintenance therapy with durvalumab to achieve disease control. On day 156 after treatment initiation, hemoglobin (Hb) levels increased to 16.9 g/dL, indicating polycythemia. Concurrently, new brain metastatic lesions were identified, and serum erythropoietin (EPO) levels were markedly elevated at 406 mIU/mL. Whole-brain radiation therapy (WBRT) was initiated, resulting in a subsequent reduction in hemoglobin levels and improvement in polycythemia. This report describes a rare case of secondary polycythemia associated with ES-SCLC. Notably, WBRT appeared to contribute to the normalization of serum EPO levels and resolution of polycythemia. This report elucidates the clinical course and relevance of this condition based on a literature review.http://www.sciencedirect.com/science/article/pii/S2213007125000760Small cell lung cancerParaneoplastic syndromePolycythemiaErythropoietin |
| spellingShingle | Takuya Tanaka Yutaka Takahara Ryudai Abe Nagae Sumito Yoko Ishige Ikuyo Shionoya Kouichi Yamamura Masafumi Nojiri Masaharu Iguchi Erythrocytosis as an indicator of disease progression of small cell lung cancer: A case report Respiratory Medicine Case Reports Small cell lung cancer Paraneoplastic syndrome Polycythemia Erythropoietin |
| title | Erythrocytosis as an indicator of disease progression of small cell lung cancer: A case report |
| title_full | Erythrocytosis as an indicator of disease progression of small cell lung cancer: A case report |
| title_fullStr | Erythrocytosis as an indicator of disease progression of small cell lung cancer: A case report |
| title_full_unstemmed | Erythrocytosis as an indicator of disease progression of small cell lung cancer: A case report |
| title_short | Erythrocytosis as an indicator of disease progression of small cell lung cancer: A case report |
| title_sort | erythrocytosis as an indicator of disease progression of small cell lung cancer a case report |
| topic | Small cell lung cancer Paraneoplastic syndrome Polycythemia Erythropoietin |
| url | http://www.sciencedirect.com/science/article/pii/S2213007125000760 |
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