Study Protocol of a Prospective Phase 2 Study of Chlorophyllin for the Management of Brain Radionecrosis in Patients With Diffuse Glioma (CHROME)

Study Protocol of a Prospective Phase 2 Study of Chlorophyllin for the Management of Brain Radionecrosis in Patients With Diffuse Glioma (CHROME)

ABSTRACT Introduction Chlorophyllin (CHL) effectively decreases the side effects of radiotherapy (RT) by scavenging radiation‐induced free radicals and reactive oxygen species in preclinical trials. This study aims to assess the efficacy of oral CHL for the treatment of brain radionecrosis in patien...

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Main Authors: Archya Dasgupta, Saranga Sawant, Abhishek Chatterjee, Vikram Gota, Arpita Sahu, Amitkumar Choudhari, Kajari Bhattacharya, Ameya Puranik, Indraja Dev, Aliasgar Moiyadi, Prakash Shetty, Vikas Singh, Nandini Menon, Sridhar Epari, Ayushi Sahay, Aekta Shah, Nazia Bano, Farnaz Shaikh, Aabha Jirage, Tejpal Gupta
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Cancer Medicine
Subjects:
chlorophyllin
diffuse glioma
glioblastoma
high‐grade glioma
radionecrosis
Online Access:https://doi.org/10.1002/cam4.70657
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