The diagnostic value of core needle biopsy in cervical cancer: A retrospective analysis.
Cervical carcinoma is a major cause of morbidity and mortality among women worldwide. Histological subtype, lymphovascular space invasion and tumor grade could have a prognostic and predictive value for patients' outcome and the knowledge of these histologic characteristics may influence clinic...
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0262257&type=printable |
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| author | Massimiliano Lia Lars-Christian Horn Paulina Sodeikat Michael Höckel Bahriye Aktas Benjamin Wolf |
| author_facet | Massimiliano Lia Lars-Christian Horn Paulina Sodeikat Michael Höckel Bahriye Aktas Benjamin Wolf |
| author_sort | Massimiliano Lia |
| collection | DOAJ |
| description | Cervical carcinoma is a major cause of morbidity and mortality among women worldwide. Histological subtype, lymphovascular space invasion and tumor grade could have a prognostic and predictive value for patients' outcome and the knowledge of these histologic characteristics may influence clinical decision making. However, studies evaluating the diagnostic value of various biopsy techniques regarding these parameters of cervical cancer are scarce. We reviewed 318 cases of cervical carcinoma with available pathology reports from preoperative core needle biopsy (CNB) assessment and from final postoperative evaluation of the hysterectomy specimen. Setting the postoperative comprehensive pathological evaluation as reference, we analysed CNB assessment of histological tumor characteristics. In addition, we performed multivariable logistic regression to identify factors influencing the accuracy in identifying LVSI and tumor grade. CNB was highly accurate in discriminating histological subtype. Sensitivity and specificity were 98.8% and 89% for squamous cell carcinoma, 92.9% and 96.6% for adenocarcinoma, 33.3% and 100% in adenosquamous carcinoma respectively. Neuroendocrine carcinoma was always recognized correctly. The accuracy of the prediction of LVSI was 61.9% and was positively influenced by tumor size in preoperative magnetic resonance imaging and negatively influenced by strong peritumoral inflammation. High tumor grade (G3) was diagnosed accurately in 73.9% of cases and was influenced by histological tumor type. In conclusion, CNB is an accurate sampling technique for histological classification of cervical cancer and represents a reasonable alternative to other biopsy techniques. |
| format | Article |
| id | doaj-art-bd46618e021d427fbffbbd6ec757535c |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-bd46618e021d427fbffbbd6ec757535c2025-08-20T03:00:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01171e026225710.1371/journal.pone.0262257The diagnostic value of core needle biopsy in cervical cancer: A retrospective analysis.Massimiliano LiaLars-Christian HornPaulina SodeikatMichael HöckelBahriye AktasBenjamin WolfCervical carcinoma is a major cause of morbidity and mortality among women worldwide. Histological subtype, lymphovascular space invasion and tumor grade could have a prognostic and predictive value for patients' outcome and the knowledge of these histologic characteristics may influence clinical decision making. However, studies evaluating the diagnostic value of various biopsy techniques regarding these parameters of cervical cancer are scarce. We reviewed 318 cases of cervical carcinoma with available pathology reports from preoperative core needle biopsy (CNB) assessment and from final postoperative evaluation of the hysterectomy specimen. Setting the postoperative comprehensive pathological evaluation as reference, we analysed CNB assessment of histological tumor characteristics. In addition, we performed multivariable logistic regression to identify factors influencing the accuracy in identifying LVSI and tumor grade. CNB was highly accurate in discriminating histological subtype. Sensitivity and specificity were 98.8% and 89% for squamous cell carcinoma, 92.9% and 96.6% for adenocarcinoma, 33.3% and 100% in adenosquamous carcinoma respectively. Neuroendocrine carcinoma was always recognized correctly. The accuracy of the prediction of LVSI was 61.9% and was positively influenced by tumor size in preoperative magnetic resonance imaging and negatively influenced by strong peritumoral inflammation. High tumor grade (G3) was diagnosed accurately in 73.9% of cases and was influenced by histological tumor type. In conclusion, CNB is an accurate sampling technique for histological classification of cervical cancer and represents a reasonable alternative to other biopsy techniques.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0262257&type=printable |
| spellingShingle | Massimiliano Lia Lars-Christian Horn Paulina Sodeikat Michael Höckel Bahriye Aktas Benjamin Wolf The diagnostic value of core needle biopsy in cervical cancer: A retrospective analysis. PLoS ONE |
| title | The diagnostic value of core needle biopsy in cervical cancer: A retrospective analysis. |
| title_full | The diagnostic value of core needle biopsy in cervical cancer: A retrospective analysis. |
| title_fullStr | The diagnostic value of core needle biopsy in cervical cancer: A retrospective analysis. |
| title_full_unstemmed | The diagnostic value of core needle biopsy in cervical cancer: A retrospective analysis. |
| title_short | The diagnostic value of core needle biopsy in cervical cancer: A retrospective analysis. |
| title_sort | diagnostic value of core needle biopsy in cervical cancer a retrospective analysis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0262257&type=printable |
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