Antioxidant Therapy in Inflammatory Bowel Diseases: How Far Have We Come and How Close Are We?
Inflammatory bowel diseases (IBD) pose a growing public health challenge with unclear etiology and limited efficacy of traditional pharmacological treatments. Alternative therapies, particularly antioxidants, have gained scientific interest. This systematic review analyzed studies from MEDLINE, Coch...
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| Format: | Article |
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MDPI AG
2024-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/13/11/1369 |
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| author | Lylian Ellen Militão dos Santos Xavier Thays Cristhyna Guimaraes Reis Amylly Sanuelly da Paz Martins Juliana Célia de Farias Santos Nassib Bezerra Bueno Marília Oliveira Fonseca Goulart Fabiana Andréa Moura |
| author_facet | Lylian Ellen Militão dos Santos Xavier Thays Cristhyna Guimaraes Reis Amylly Sanuelly da Paz Martins Juliana Célia de Farias Santos Nassib Bezerra Bueno Marília Oliveira Fonseca Goulart Fabiana Andréa Moura |
| author_sort | Lylian Ellen Militão dos Santos Xavier |
| collection | DOAJ |
| description | Inflammatory bowel diseases (IBD) pose a growing public health challenge with unclear etiology and limited efficacy of traditional pharmacological treatments. Alternative therapies, particularly antioxidants, have gained scientific interest. This systematic review analyzed studies from MEDLINE, Cochrane, Web of Science, EMBASE, and Scopus using keywords like “Inflammatory Bowel Diseases” and “Antioxidants.” Initially, 925 publications were identified, and after applying inclusion/exclusion criteria—covering studies from July 2015 to June 2024 using murine models or clinical trials in humans and evaluating natural or synthetic substances affecting oxidative stress markers—368 articles were included. This comprised 344 animal studies and 24 human studies. The most investigated antioxidants were polyphenols and active compounds from medicinal plants (n = 242; 70.3%). The review found a strong link between oxidative stress and inflammation in IBD, especially in studies on nuclear factor kappa B and nuclear factor erythroid 2-related factor 2 pathways. However, it remains unclear whether inflammation or oxidative stress occurs first in IBD. Lipid peroxidation was the most studied oxidative damage, followed by DNA damage. Protein damage was rarely investigated. The relationship between antioxidants and the gut microbiota was examined in 103 animal studies. Human studies evaluating oxidative stress markers were scarce, reflecting a major research gap in IBD treatment. PROSPERO registration: CDR42022335357 and CRD42022304540. |
| format | Article |
| id | doaj-art-bd4521ef52fd46ea99e6b1f1f0942536 |
| institution | OA Journals |
| issn | 2076-3921 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-bd4521ef52fd46ea99e6b1f1f09425362025-08-20T02:26:45ZengMDPI AGAntioxidants2076-39212024-11-011311136910.3390/antiox13111369Antioxidant Therapy in Inflammatory Bowel Diseases: How Far Have We Come and How Close Are We?Lylian Ellen Militão dos Santos Xavier0Thays Cristhyna Guimaraes Reis1Amylly Sanuelly da Paz Martins2Juliana Célia de Farias Santos3Nassib Bezerra Bueno4Marília Oliveira Fonseca Goulart5Fabiana Andréa Moura6Postgraduate Degree in Nutrition (PPGNUT), Federal University of Alagoas (UFAL), Maceió 57072-970, AL, BrazilFaculty of Nutrition (FANUT), Federal University of Alagoas (UFAL), Maceió 57072-970, AL, BrazilPostgraduate Studies at the Northeast Biotechnology Network (RENORBIO), Federal University of Alagoas (UFAL), Maceió 57072-970, AL, BrazilPostgraduate Degree in Medical Sciences (PPGCM/UFAL), Federal University of Alagoas (UFAL), Maceió 57072-970, AL, BrazilPostgraduate Degree in Nutrition (PPGNUT), Federal University of Alagoas (UFAL), Maceió 57072-970, AL, BrazilPostgraduate Studies at the Northeast Biotechnology Network (RENORBIO), Federal University of Alagoas (UFAL), Maceió 57072-970, AL, BrazilPostgraduate Degree in Nutrition (PPGNUT), Federal University of Alagoas (UFAL), Maceió 57072-970, AL, BrazilInflammatory bowel diseases (IBD) pose a growing public health challenge with unclear etiology and limited efficacy of traditional pharmacological treatments. Alternative therapies, particularly antioxidants, have gained scientific interest. This systematic review analyzed studies from MEDLINE, Cochrane, Web of Science, EMBASE, and Scopus using keywords like “Inflammatory Bowel Diseases” and “Antioxidants.” Initially, 925 publications were identified, and after applying inclusion/exclusion criteria—covering studies from July 2015 to June 2024 using murine models or clinical trials in humans and evaluating natural or synthetic substances affecting oxidative stress markers—368 articles were included. This comprised 344 animal studies and 24 human studies. The most investigated antioxidants were polyphenols and active compounds from medicinal plants (n = 242; 70.3%). The review found a strong link between oxidative stress and inflammation in IBD, especially in studies on nuclear factor kappa B and nuclear factor erythroid 2-related factor 2 pathways. However, it remains unclear whether inflammation or oxidative stress occurs first in IBD. Lipid peroxidation was the most studied oxidative damage, followed by DNA damage. Protein damage was rarely investigated. The relationship between antioxidants and the gut microbiota was examined in 103 animal studies. Human studies evaluating oxidative stress markers were scarce, reflecting a major research gap in IBD treatment. PROSPERO registration: CDR42022335357 and CRD42022304540.https://www.mdpi.com/2076-3921/13/11/1369oxidative stressbiomarkerscomplementary and alternative medicineulcerative colitisCrohn’s disease |
| spellingShingle | Lylian Ellen Militão dos Santos Xavier Thays Cristhyna Guimaraes Reis Amylly Sanuelly da Paz Martins Juliana Célia de Farias Santos Nassib Bezerra Bueno Marília Oliveira Fonseca Goulart Fabiana Andréa Moura Antioxidant Therapy in Inflammatory Bowel Diseases: How Far Have We Come and How Close Are We? Antioxidants oxidative stress biomarkers complementary and alternative medicine ulcerative colitis Crohn’s disease |
| title | Antioxidant Therapy in Inflammatory Bowel Diseases: How Far Have We Come and How Close Are We? |
| title_full | Antioxidant Therapy in Inflammatory Bowel Diseases: How Far Have We Come and How Close Are We? |
| title_fullStr | Antioxidant Therapy in Inflammatory Bowel Diseases: How Far Have We Come and How Close Are We? |
| title_full_unstemmed | Antioxidant Therapy in Inflammatory Bowel Diseases: How Far Have We Come and How Close Are We? |
| title_short | Antioxidant Therapy in Inflammatory Bowel Diseases: How Far Have We Come and How Close Are We? |
| title_sort | antioxidant therapy in inflammatory bowel diseases how far have we come and how close are we |
| topic | oxidative stress biomarkers complementary and alternative medicine ulcerative colitis Crohn’s disease |
| url | https://www.mdpi.com/2076-3921/13/11/1369 |
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