Acute graft-versus-host disease: a case report
We report successful treatment of a case with acute graft-versus-host disease. A 54-year-old male presented with a fever for two weeks and generalized pruritic erythemas for three days. The patient had allogeneic liver transplantation one month ago. Dermatological examination revealed lip erosion wi...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology
2025-01-01
|
| Series: | Pifu-xingbing zhenliaoxue zazhi |
| Subjects: | |
| Online Access: | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2025.01.009 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825199604642086912 |
|---|---|
| author | JIANG Yuyang TANG Lulu CHEN Haiju LV Chunying XIONG Hongdi WU Yi |
| author_facet | JIANG Yuyang TANG Lulu CHEN Haiju LV Chunying XIONG Hongdi WU Yi |
| author_sort | JIANG Yuyang |
| collection | DOAJ |
| description | We report successful treatment of a case with acute graft-versus-host disease. A 54-year-old male presented with a fever for two weeks and generalized pruritic erythemas for three days. The patient had allogeneic liver transplantation one month ago. Dermatological examination revealed lip erosion with purulent discharge, multiple erythematous rashes on the head, face, trunk, and extremities. Normal skin islands could be seen between some erythemas, and both palms had targetoid erythema. A surgical scar approximately 35 cm in length was observed below the rib margin. Histopathological changes included extensive epidermal necrosis with satellite lymphocytic infiltration surrounding necrotic keratinocytes in the epidermis, subepidermal clefts, mild perivascular lymphocytic infiltration in the superficial dermis, focal necrosis of follicular epithelium, and a few lymphocytic infiltrations around sweat glands. A diagnosis of acute graft-versus-host disease was made. The patient was treated with high dose glucocorticoids and human immunoglobulin. The treatments improved both erythema and other conditions, and the patient was discharged. No new lesions or liver transplant rejection occurred during 4-month follow-up. |
| format | Article |
| id | doaj-art-bd415ec775ea4b089da599c3a6dedd4e |
| institution | Kabale University |
| issn | 1674-8468 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology |
| record_format | Article |
| series | Pifu-xingbing zhenliaoxue zazhi |
| spelling | doaj-art-bd415ec775ea4b089da599c3a6dedd4e2025-02-08T03:48:35Zzhoeditoiral office of Journal of Diagnosis and Therapy on Dermato-venereologyPifu-xingbing zhenliaoxue zazhi1674-84682025-01-01321515510.3969/j.issn.1674-8468.2025.01.009Acute graft-versus-host disease: a case reportJIANG Yuyang0TANG Lulu1CHEN Haiju2LV Chunying3XIONG Hongdi4WU Yi5Second Affiliated Hospital of Guangxi Medical University, Nanning 530000, ChinaSecond Affiliated Hospital of Guangxi Medical University, Nanning 530000, ChinaSecond Affiliated Hospital of Guangxi Medical University, Nanning 530000, ChinaSecond Affiliated Hospital of Guangxi Medical University, Nanning 530000, ChinaSecond Affiliated Hospital of Guangxi Medical University, Nanning 530000, ChinaSecond Affiliated Hospital of Guangxi Medical University, Nanning 530000, ChinaWe report successful treatment of a case with acute graft-versus-host disease. A 54-year-old male presented with a fever for two weeks and generalized pruritic erythemas for three days. The patient had allogeneic liver transplantation one month ago. Dermatological examination revealed lip erosion with purulent discharge, multiple erythematous rashes on the head, face, trunk, and extremities. Normal skin islands could be seen between some erythemas, and both palms had targetoid erythema. A surgical scar approximately 35 cm in length was observed below the rib margin. Histopathological changes included extensive epidermal necrosis with satellite lymphocytic infiltration surrounding necrotic keratinocytes in the epidermis, subepidermal clefts, mild perivascular lymphocytic infiltration in the superficial dermis, focal necrosis of follicular epithelium, and a few lymphocytic infiltrations around sweat glands. A diagnosis of acute graft-versus-host disease was made. The patient was treated with high dose glucocorticoids and human immunoglobulin. The treatments improved both erythema and other conditions, and the patient was discharged. No new lesions or liver transplant rejection occurred during 4-month follow-up.http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2025.01.009acute graft-versus-host diseaseliver transplantationdrug induced dermatitis |
| spellingShingle | JIANG Yuyang TANG Lulu CHEN Haiju LV Chunying XIONG Hongdi WU Yi Acute graft-versus-host disease: a case report Pifu-xingbing zhenliaoxue zazhi acute graft-versus-host disease liver transplantation drug induced dermatitis |
| title | Acute graft-versus-host disease: a case report |
| title_full | Acute graft-versus-host disease: a case report |
| title_fullStr | Acute graft-versus-host disease: a case report |
| title_full_unstemmed | Acute graft-versus-host disease: a case report |
| title_short | Acute graft-versus-host disease: a case report |
| title_sort | acute graft versus host disease a case report |
| topic | acute graft-versus-host disease liver transplantation drug induced dermatitis |
| url | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2025.01.009 |
| work_keys_str_mv | AT jiangyuyang acutegraftversushostdiseaseacasereport AT tanglulu acutegraftversushostdiseaseacasereport AT chenhaiju acutegraftversushostdiseaseacasereport AT lvchunying acutegraftversushostdiseaseacasereport AT xionghongdi acutegraftversushostdiseaseacasereport AT wuyi acutegraftversushostdiseaseacasereport |