Acute graft-versus-host disease: a case report
We report successful treatment of a case with acute graft-versus-host disease. A 54-year-old male presented with a fever for two weeks and generalized pruritic erythemas for three days. The patient had allogeneic liver transplantation one month ago. Dermatological examination revealed lip erosion wi...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology
2025-01-01
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| Series: | Pifu-xingbing zhenliaoxue zazhi |
| Subjects: | |
| Online Access: | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2025.01.009 |
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| Summary: | We report successful treatment of a case with acute graft-versus-host disease. A 54-year-old male presented with a fever for two weeks and generalized pruritic erythemas for three days. The patient had allogeneic liver transplantation one month ago. Dermatological examination revealed lip erosion with purulent discharge, multiple erythematous rashes on the head, face, trunk, and extremities. Normal skin islands could be seen between some erythemas, and both palms had targetoid erythema. A surgical scar approximately 35 cm in length was observed below the rib margin. Histopathological changes included extensive epidermal necrosis with satellite lymphocytic infiltration surrounding necrotic keratinocytes in the epidermis, subepidermal clefts, mild perivascular lymphocytic infiltration in the superficial dermis, focal necrosis of follicular epithelium, and a few lymphocytic infiltrations around sweat glands. A diagnosis of acute graft-versus-host disease was made. The patient was treated with high dose glucocorticoids and human immunoglobulin. The treatments improved both erythema and other conditions, and the patient was discharged. No new lesions or liver transplant rejection occurred during 4-month follow-up. |
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| ISSN: | 1674-8468 |