The Adverse Effects of Air Pollution on the Nervous System
Exposure to ambient air pollution is a serious and common public health concern associated with growing morbidity and mortality worldwide. In the last decades, the adverse effects of air pollution on the pulmonary and cardiovascular systems have been well established in a series of major epidemiolog...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2012/782462 |
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| author | Sermin Genc Zeynep Zadeoglulari Stefan H. Fuss Kursad Genc |
| author_facet | Sermin Genc Zeynep Zadeoglulari Stefan H. Fuss Kursad Genc |
| author_sort | Sermin Genc |
| collection | DOAJ |
| description | Exposure to ambient air pollution is a serious and common public health concern associated with growing morbidity and mortality worldwide. In the last decades, the adverse effects of air pollution on the pulmonary and cardiovascular systems have been well established in a series of major epidemiological and observational studies. In the recent past, air pollution has also been associated with diseases of the central nervous system (CNS), including stroke, Alzheimer’s disease, Parkinson’s disease, and neurodevelopmental disorders. It has been demonstrated that various components of air pollution, such as nanosized particles, can easily translocate to the CNS where they can activate innate immune responses. Furthermore, systemic inflammation arising from the pulmonary or cardiovascular system can affect CNS health. Despite intense studies on the health effects of ambient air pollution, the underlying molecular mechanisms of susceptibility and disease remain largely elusive. However, emerging evidence suggests that air pollution-induced neuroinflammation, oxidative stress, microglial activation, cerebrovascular dysfunction, and alterations in the blood-brain barrier contribute to CNS pathology. A better understanding of the mediators and mechanisms will enable the development of new strategies to protect individuals at risk and to reduce detrimental effects of air pollution on the nervous system and mental health. |
| format | Article |
| id | doaj-art-bd4010de7b0c43cbb20cc12661fa855f |
| institution | OA Journals |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-bd4010de7b0c43cbb20cc12661fa855f2025-08-20T02:19:12ZengWileyJournal of Toxicology1687-81911687-82052012-01-01201210.1155/2012/782462782462The Adverse Effects of Air Pollution on the Nervous SystemSermin Genc0Zeynep Zadeoglulari1Stefan H. Fuss2Kursad Genc3Department of Neuroscience, Health Science Institute, Dokuz Eylul University, Inciralti, 35340 Izmir, TurkeyDepartment of Neuroscience, Health Science Institute, Dokuz Eylul University, Inciralti, 35340 Izmir, TurkeyDepartment of Molecular Biology and Genetics, Bogazici University, 34342 Istanbul, TurkeyDepartment of Neuroscience, Health Science Institute, Dokuz Eylul University, Inciralti, 35340 Izmir, TurkeyExposure to ambient air pollution is a serious and common public health concern associated with growing morbidity and mortality worldwide. In the last decades, the adverse effects of air pollution on the pulmonary and cardiovascular systems have been well established in a series of major epidemiological and observational studies. In the recent past, air pollution has also been associated with diseases of the central nervous system (CNS), including stroke, Alzheimer’s disease, Parkinson’s disease, and neurodevelopmental disorders. It has been demonstrated that various components of air pollution, such as nanosized particles, can easily translocate to the CNS where they can activate innate immune responses. Furthermore, systemic inflammation arising from the pulmonary or cardiovascular system can affect CNS health. Despite intense studies on the health effects of ambient air pollution, the underlying molecular mechanisms of susceptibility and disease remain largely elusive. However, emerging evidence suggests that air pollution-induced neuroinflammation, oxidative stress, microglial activation, cerebrovascular dysfunction, and alterations in the blood-brain barrier contribute to CNS pathology. A better understanding of the mediators and mechanisms will enable the development of new strategies to protect individuals at risk and to reduce detrimental effects of air pollution on the nervous system and mental health.http://dx.doi.org/10.1155/2012/782462 |
| spellingShingle | Sermin Genc Zeynep Zadeoglulari Stefan H. Fuss Kursad Genc The Adverse Effects of Air Pollution on the Nervous System Journal of Toxicology |
| title | The Adverse Effects of Air Pollution on the Nervous System |
| title_full | The Adverse Effects of Air Pollution on the Nervous System |
| title_fullStr | The Adverse Effects of Air Pollution on the Nervous System |
| title_full_unstemmed | The Adverse Effects of Air Pollution on the Nervous System |
| title_short | The Adverse Effects of Air Pollution on the Nervous System |
| title_sort | adverse effects of air pollution on the nervous system |
| url | http://dx.doi.org/10.1155/2012/782462 |
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