Bicuspid Aortic Valve and Sudden Cardiac Death
Bicuspid aortic valve (BAV) is the most common congenital heart anomaly, affecting an estimated 0.5% to 0.77% of the general population. This condition occurs when the aortic valve has only two cusps instead of the usual three, disrupting normal valve function and increasing the risk of various card...
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MDPI AG
2025-05-01
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| Online Access: | https://www.mdpi.com/2075-1729/15/6/868 |
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| author | Cecilia Salzillo Andrea Quaranta Fabrizia Di Lizia Michela Lombardo Marco Matteo Ciccone Vincenzo Ezio Santobuono Enrica Macorano Francesco Introna Biagio Solarino Andrea Marzullo |
| author_facet | Cecilia Salzillo Andrea Quaranta Fabrizia Di Lizia Michela Lombardo Marco Matteo Ciccone Vincenzo Ezio Santobuono Enrica Macorano Francesco Introna Biagio Solarino Andrea Marzullo |
| author_sort | Cecilia Salzillo |
| collection | DOAJ |
| description | Bicuspid aortic valve (BAV) is the most common congenital heart anomaly, affecting an estimated 0.5% to 0.77% of the general population. This condition occurs when the aortic valve has only two cusps instead of the usual three, disrupting normal valve function and increasing the risk of various cardiovascular diseases. Often asymptomatic in its early stages, BAV can gradually progress, leading to stenosis, valve insufficiency, and abnormalities of the ascending aorta. One particularly concerning aspect is its potential association with sudden cardiac death (SCD). The aim of this literature review is to examine the relationship between BAV and the risk of SCD, highlighting the pathogenic variants and pathophysiological mechanisms involved while emphasizing the significance of valve classification and its clinical implications. Additionally, it explores current research gaps and future directions to enhance early identification of at-risk individuals and reduce the incidence of SCD. |
| format | Article |
| id | doaj-art-bd374abd46224eeaa9c77b8d6c6c045c |
| institution | Kabale University |
| issn | 2075-1729 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-bd374abd46224eeaa9c77b8d6c6c045c2025-08-20T03:27:21ZengMDPI AGLife2075-17292025-05-0115686810.3390/life15060868Bicuspid Aortic Valve and Sudden Cardiac DeathCecilia Salzillo0Andrea Quaranta1Fabrizia Di Lizia2Michela Lombardo3Marco Matteo Ciccone4Vincenzo Ezio Santobuono5Enrica Macorano6Francesco Introna7Biagio Solarino8Andrea Marzullo9PhD Course in Public Health, Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyPathology Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari “Aldo Moro”, 70124 Bari, ItalyPathology Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari “Aldo Moro”, 70124 Bari, ItalyPathology Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari “Aldo Moro”, 70124 Bari, ItalyCardiology Unit, Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyCardiology Unit, Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyLegal Medicine Unit, Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyLegal Medicine Unit, Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyLegal Medicine Unit, Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyPathology Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari “Aldo Moro”, 70124 Bari, ItalyBicuspid aortic valve (BAV) is the most common congenital heart anomaly, affecting an estimated 0.5% to 0.77% of the general population. This condition occurs when the aortic valve has only two cusps instead of the usual three, disrupting normal valve function and increasing the risk of various cardiovascular diseases. Often asymptomatic in its early stages, BAV can gradually progress, leading to stenosis, valve insufficiency, and abnormalities of the ascending aorta. One particularly concerning aspect is its potential association with sudden cardiac death (SCD). The aim of this literature review is to examine the relationship between BAV and the risk of SCD, highlighting the pathogenic variants and pathophysiological mechanisms involved while emphasizing the significance of valve classification and its clinical implications. Additionally, it explores current research gaps and future directions to enhance early identification of at-risk individuals and reduce the incidence of SCD.https://www.mdpi.com/2075-1729/15/6/868bicuspid aortic valvepathogenic variantsclassification valvularsudden cardiac deathcardiovascular complicationspreventive strategies |
| spellingShingle | Cecilia Salzillo Andrea Quaranta Fabrizia Di Lizia Michela Lombardo Marco Matteo Ciccone Vincenzo Ezio Santobuono Enrica Macorano Francesco Introna Biagio Solarino Andrea Marzullo Bicuspid Aortic Valve and Sudden Cardiac Death Life bicuspid aortic valve pathogenic variants classification valvular sudden cardiac death cardiovascular complications preventive strategies |
| title | Bicuspid Aortic Valve and Sudden Cardiac Death |
| title_full | Bicuspid Aortic Valve and Sudden Cardiac Death |
| title_fullStr | Bicuspid Aortic Valve and Sudden Cardiac Death |
| title_full_unstemmed | Bicuspid Aortic Valve and Sudden Cardiac Death |
| title_short | Bicuspid Aortic Valve and Sudden Cardiac Death |
| title_sort | bicuspid aortic valve and sudden cardiac death |
| topic | bicuspid aortic valve pathogenic variants classification valvular sudden cardiac death cardiovascular complications preventive strategies |
| url | https://www.mdpi.com/2075-1729/15/6/868 |
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