Changes in Serum Inflammatory Markers and in Clinical Periodontal Condition After Non-Surgical Periodontal Treatment in Hypertensive Patients
Background: Chronic inflammatory disorders, such as periodontitis, may contribute to pro-hypertensive inflammation. Objectives: This study aimed to analyze changes in parameters for periodontitis, such as periodontal inflamed surface area (PISA) and serum inflammatory markers, following non-surgical...
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MDPI AG
2025-02-01
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| Online Access: | https://www.mdpi.com/2227-9059/13/2/374 |
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| author | Francina María Escobar Arregoces Nelly S. Roa Juliana Velosa-Porras Lina Velásquez Rodríguez María José Merchan Jean Carlos Villamil Poveda Liliana Otero Álvaro J. Ruiz Catalina Latorre Uriza |
| author_facet | Francina María Escobar Arregoces Nelly S. Roa Juliana Velosa-Porras Lina Velásquez Rodríguez María José Merchan Jean Carlos Villamil Poveda Liliana Otero Álvaro J. Ruiz Catalina Latorre Uriza |
| author_sort | Francina María Escobar Arregoces |
| collection | DOAJ |
| description | Background: Chronic inflammatory disorders, such as periodontitis, may contribute to pro-hypertensive inflammation. Objectives: This study aimed to analyze changes in parameters for periodontitis, such as periodontal inflamed surface area (PISA) and serum inflammatory markers, following non-surgical periodontal treatment in hypertensive patients. Methods: A quasi-experimental pre-and-post study was conducted, involving 42 controlled hypertensive patients with periodontitis. The patients underwent periodontal assessment and tests, including complete blood count, glucose, triglycerides, HDL-C, LDL-C, and serum levels of inflammatory biomarkers. All patients received scaling and root planning treatment in a single session and were reevaluated one month after the treatment. Results: Post-treatment evaluations showed significant improvements in periodontal inflammation parameters, such as pocket depth, attachment level, bleeding on probing, and biofilm percentage, with statistically significant differences (<i>p</i> < 0.001). There were decreases in serum VEGF levels (<i>p</i> < 0.001) and reductions in PISA associated with declines in cytokine levels such as IL-10, IL-6, IL-12p70, IL-17A, and VEGF. PISA for IL-6 and IL-10 had a positive correlation before periodontal treatment and with IL-1β and IL-10 after treatment. Conclusions: Hypertensive patients with periodontitis who underwent non-surgical periodontal treatment showed improvements in their periodontal condition, a decrease in cytokine levels such as VEGF, and reductions in PISA associated with declines in cytokines such as IL-10, IL-6, IL-12p70, IL-17A, and VEGF. These findings confirm the role of inflammation in hypertensive patients with periodontitis. |
| format | Article |
| id | doaj-art-bd36367e26744eacbf620fddb5ce408d |
| institution | DOAJ |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj-art-bd36367e26744eacbf620fddb5ce408d2025-08-20T02:44:49ZengMDPI AGBiomedicines2227-90592025-02-0113237410.3390/biomedicines13020374Changes in Serum Inflammatory Markers and in Clinical Periodontal Condition After Non-Surgical Periodontal Treatment in Hypertensive PatientsFrancina María Escobar Arregoces0Nelly S. Roa1Juliana Velosa-Porras2Lina Velásquez Rodríguez3María José Merchan4Jean Carlos Villamil Poveda5Liliana Otero6Álvaro J. Ruiz7Catalina Latorre Uriza8Centro de Investigaciones Odontológicas (CIO), Faculty of Dentistry, Pontificia Universidad Javeriana, Bogotá 110311, ColombiaCentro de Investigaciones Odontológicas (CIO), Faculty of Dentistry, Pontificia Universidad Javeriana, Bogotá 110311, ColombiaCentro de Investigaciones Odontológicas (CIO), Faculty of Dentistry, Pontificia Universidad Javeriana, Bogotá 110311, ColombiaFaculty of Dentistry, Pontificia Universidad Javeriana, Bogotá 110311, ColombiaFaculty of Dentistry, Pontificia Universidad Javeriana, Bogotá 110311, ColombiaCentro de Investigaciones Odontológicas (CIO), Faculty of Dentistry, Pontificia Universidad Javeriana, Bogotá 110311, ColombiaCentro de Investigaciones Odontológicas (CIO), Faculty of Dentistry, Pontificia Universidad Javeriana, Bogotá 110311, ColombiaDepartamento de Medicina Interna, Faculty of Medicine, Pontificia Universidad Javeriana, Bogotá 110311, ColombiaCentro de Investigaciones Odontológicas (CIO), Faculty of Dentistry, Pontificia Universidad Javeriana, Bogotá 110311, ColombiaBackground: Chronic inflammatory disorders, such as periodontitis, may contribute to pro-hypertensive inflammation. Objectives: This study aimed to analyze changes in parameters for periodontitis, such as periodontal inflamed surface area (PISA) and serum inflammatory markers, following non-surgical periodontal treatment in hypertensive patients. Methods: A quasi-experimental pre-and-post study was conducted, involving 42 controlled hypertensive patients with periodontitis. The patients underwent periodontal assessment and tests, including complete blood count, glucose, triglycerides, HDL-C, LDL-C, and serum levels of inflammatory biomarkers. All patients received scaling and root planning treatment in a single session and were reevaluated one month after the treatment. Results: Post-treatment evaluations showed significant improvements in periodontal inflammation parameters, such as pocket depth, attachment level, bleeding on probing, and biofilm percentage, with statistically significant differences (<i>p</i> < 0.001). There were decreases in serum VEGF levels (<i>p</i> < 0.001) and reductions in PISA associated with declines in cytokine levels such as IL-10, IL-6, IL-12p70, IL-17A, and VEGF. PISA for IL-6 and IL-10 had a positive correlation before periodontal treatment and with IL-1β and IL-10 after treatment. Conclusions: Hypertensive patients with periodontitis who underwent non-surgical periodontal treatment showed improvements in their periodontal condition, a decrease in cytokine levels such as VEGF, and reductions in PISA associated with declines in cytokines such as IL-10, IL-6, IL-12p70, IL-17A, and VEGF. These findings confirm the role of inflammation in hypertensive patients with periodontitis.https://www.mdpi.com/2227-9059/13/2/374hypertensionperiodontal diseaseperiodontitisperiodontal infectionperiodontal debridementinflammation mediators |
| spellingShingle | Francina María Escobar Arregoces Nelly S. Roa Juliana Velosa-Porras Lina Velásquez Rodríguez María José Merchan Jean Carlos Villamil Poveda Liliana Otero Álvaro J. Ruiz Catalina Latorre Uriza Changes in Serum Inflammatory Markers and in Clinical Periodontal Condition After Non-Surgical Periodontal Treatment in Hypertensive Patients Biomedicines hypertension periodontal disease periodontitis periodontal infection periodontal debridement inflammation mediators |
| title | Changes in Serum Inflammatory Markers and in Clinical Periodontal Condition After Non-Surgical Periodontal Treatment in Hypertensive Patients |
| title_full | Changes in Serum Inflammatory Markers and in Clinical Periodontal Condition After Non-Surgical Periodontal Treatment in Hypertensive Patients |
| title_fullStr | Changes in Serum Inflammatory Markers and in Clinical Periodontal Condition After Non-Surgical Periodontal Treatment in Hypertensive Patients |
| title_full_unstemmed | Changes in Serum Inflammatory Markers and in Clinical Periodontal Condition After Non-Surgical Periodontal Treatment in Hypertensive Patients |
| title_short | Changes in Serum Inflammatory Markers and in Clinical Periodontal Condition After Non-Surgical Periodontal Treatment in Hypertensive Patients |
| title_sort | changes in serum inflammatory markers and in clinical periodontal condition after non surgical periodontal treatment in hypertensive patients |
| topic | hypertension periodontal disease periodontitis periodontal infection periodontal debridement inflammation mediators |
| url | https://www.mdpi.com/2227-9059/13/2/374 |
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