PAIN AND INFLAMMATION. PART 2. THE ANALGESIC POTENTIAL OF ANTI-INFLAMMATORY DRUGS
An inflammatory response and the development of pain are interdependent processes. Inflammation accompanied by the overproduction of proinflammatory cytokines and mediators not only causes pain, but is also the main cause of its chronicity. Therefore, the use of anti-inflammatory drugs should be con...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2017-03-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/2340 |
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| author | A. E. Karateev D. E. Karateev O. S. Davydov |
| author_facet | A. E. Karateev D. E. Karateev O. S. Davydov |
| author_sort | A. E. Karateev |
| collection | DOAJ |
| description | An inflammatory response and the development of pain are interdependent processes. Inflammation accompanied by the overproduction of proinflammatory cytokines and mediators not only causes pain, but is also the main cause of its chronicity. Therefore, the use of anti-inflammatory drugs should be considered to be the mainstay of analgesic therapy. Part 2 of the review discusses the analgesic potential of various pharmacological groups that have an anti-inflammatory effect: nonsteroidal anti-inflammatory drugs, glucocorticoids, biological agents, methotrexate, slow-acting antiinflammatory drugs (chondroprotectors), as well as a number of promising and experimental agents, such as nerve growth factor inhibitors. It provides data from major clinical trials that have evaluated the analgesic effect of these drugs in various diseases and pathological conditions. |
| format | Article |
| id | doaj-art-bd324dcfe9ea49a5b37d291e21c6f6d7 |
| institution | DOAJ |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2017-03-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-bd324dcfe9ea49a5b37d291e21c6f6d72025-08-20T02:55:19ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922017-03-01551586710.14412/1995-4484-2017-58-672201PAIN AND INFLAMMATION. PART 2. THE ANALGESIC POTENTIAL OF ANTI-INFLAMMATORY DRUGSA. E. Karateev0D. E. Karateev1O. S. Davydov2V.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyZ.P. Solovyev Research and Practical Center of PsychoneurologyAn inflammatory response and the development of pain are interdependent processes. Inflammation accompanied by the overproduction of proinflammatory cytokines and mediators not only causes pain, but is also the main cause of its chronicity. Therefore, the use of anti-inflammatory drugs should be considered to be the mainstay of analgesic therapy. Part 2 of the review discusses the analgesic potential of various pharmacological groups that have an anti-inflammatory effect: nonsteroidal anti-inflammatory drugs, glucocorticoids, biological agents, methotrexate, slow-acting antiinflammatory drugs (chondroprotectors), as well as a number of promising and experimental agents, such as nerve growth factor inhibitors. It provides data from major clinical trials that have evaluated the analgesic effect of these drugs in various diseases and pathological conditions.https://rsp.mediar-press.net/rsp/article/view/2340paininflammationparacetamolnonsteroidal anti-inflammatory drugsglucocorticoidsmethotrexatebiological agentsnerve growth factor inhibitors |
| spellingShingle | A. E. Karateev D. E. Karateev O. S. Davydov PAIN AND INFLAMMATION. PART 2. THE ANALGESIC POTENTIAL OF ANTI-INFLAMMATORY DRUGS Научно-практическая ревматология pain inflammation paracetamol nonsteroidal anti-inflammatory drugs glucocorticoids methotrexate biological agents nerve growth factor inhibitors |
| title | PAIN AND INFLAMMATION. PART 2. THE ANALGESIC POTENTIAL OF ANTI-INFLAMMATORY DRUGS |
| title_full | PAIN AND INFLAMMATION. PART 2. THE ANALGESIC POTENTIAL OF ANTI-INFLAMMATORY DRUGS |
| title_fullStr | PAIN AND INFLAMMATION. PART 2. THE ANALGESIC POTENTIAL OF ANTI-INFLAMMATORY DRUGS |
| title_full_unstemmed | PAIN AND INFLAMMATION. PART 2. THE ANALGESIC POTENTIAL OF ANTI-INFLAMMATORY DRUGS |
| title_short | PAIN AND INFLAMMATION. PART 2. THE ANALGESIC POTENTIAL OF ANTI-INFLAMMATORY DRUGS |
| title_sort | pain and inflammation part 2 the analgesic potential of anti inflammatory drugs |
| topic | pain inflammation paracetamol nonsteroidal anti-inflammatory drugs glucocorticoids methotrexate biological agents nerve growth factor inhibitors |
| url | https://rsp.mediar-press.net/rsp/article/view/2340 |
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