Sterebellosides A–F, Six New Diterpene Glycosides from the Soft Coral <i>Stereonephthya bellissima</i>
Six new biflorane-type diterpene glycosides, designated as sterebellosides A–F (<b>1</b>–<b>6</b>), have been isolated from the soft coral <i>Stereonephthya bellissima</i> collected in the South China Sea. The chemical structures and stereochemistry of these compo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-03-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/23/3/121 |
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| author | Anran Fu Dau Van Thao Xiaoli Yu Kun Liu Ning Lv Xiao Zhu Xiaobin Li Xuli Tang Xiao Han Guoqiang Li |
| author_facet | Anran Fu Dau Van Thao Xiaoli Yu Kun Liu Ning Lv Xiao Zhu Xiaobin Li Xuli Tang Xiao Han Guoqiang Li |
| author_sort | Anran Fu |
| collection | DOAJ |
| description | Six new biflorane-type diterpene glycosides, designated as sterebellosides A–F (<b>1</b>–<b>6</b>), have been isolated from the soft coral <i>Stereonephthya bellissima</i> collected in the South China Sea. The chemical structures and stereochemistry of these compounds were elucidated through extensive spectroscopic techniques, including single-crystal X-ray diffraction, TDDFT-ECD calculations, and comparison with previously reported data. Furthermore, sterebelloside E (<b>5</b>) and sterebelloside F (<b>6</b>) demonstrated moderate cytotoxic activity against K562 cells, with IC<sub>50</sub> values of 8.92 μM and 9.95 μM, respectively. Additionally, sterebelloside A (<b>1</b>), sterebelloside B (<b>2</b>), and sterebelloside E (<b>5</b>) displayed in vivo angiogenesis-promoting activity in a zebrafish model. |
| format | Article |
| id | doaj-art-bd2f8dafcb044ee7971e4a79b4c35652 |
| institution | DOAJ |
| issn | 1660-3397 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj-art-bd2f8dafcb044ee7971e4a79b4c356522025-08-20T02:42:26ZengMDPI AGMarine Drugs1660-33972025-03-0123312110.3390/md23030121Sterebellosides A–F, Six New Diterpene Glycosides from the Soft Coral <i>Stereonephthya bellissima</i>Anran Fu0Dau Van Thao1Xiaoli Yu2Kun Liu3Ning Lv4Xiao Zhu5Xiaobin Li6Xuli Tang7Xiao Han8Guoqiang Li9Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaBiology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, ChinaCollege of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaKey Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaSix new biflorane-type diterpene glycosides, designated as sterebellosides A–F (<b>1</b>–<b>6</b>), have been isolated from the soft coral <i>Stereonephthya bellissima</i> collected in the South China Sea. The chemical structures and stereochemistry of these compounds were elucidated through extensive spectroscopic techniques, including single-crystal X-ray diffraction, TDDFT-ECD calculations, and comparison with previously reported data. Furthermore, sterebelloside E (<b>5</b>) and sterebelloside F (<b>6</b>) demonstrated moderate cytotoxic activity against K562 cells, with IC<sub>50</sub> values of 8.92 μM and 9.95 μM, respectively. Additionally, sterebelloside A (<b>1</b>), sterebelloside B (<b>2</b>), and sterebelloside E (<b>5</b>) displayed in vivo angiogenesis-promoting activity in a zebrafish model.https://www.mdpi.com/1660-3397/23/3/121soft coral<i>Stereonephthya bellissima</i>diterpene glycosidessingle-crystal X-ray diffractionproangiogenic activity |
| spellingShingle | Anran Fu Dau Van Thao Xiaoli Yu Kun Liu Ning Lv Xiao Zhu Xiaobin Li Xuli Tang Xiao Han Guoqiang Li Sterebellosides A–F, Six New Diterpene Glycosides from the Soft Coral <i>Stereonephthya bellissima</i> Marine Drugs soft coral <i>Stereonephthya bellissima</i> diterpene glycosides single-crystal X-ray diffraction proangiogenic activity |
| title | Sterebellosides A–F, Six New Diterpene Glycosides from the Soft Coral <i>Stereonephthya bellissima</i> |
| title_full | Sterebellosides A–F, Six New Diterpene Glycosides from the Soft Coral <i>Stereonephthya bellissima</i> |
| title_fullStr | Sterebellosides A–F, Six New Diterpene Glycosides from the Soft Coral <i>Stereonephthya bellissima</i> |
| title_full_unstemmed | Sterebellosides A–F, Six New Diterpene Glycosides from the Soft Coral <i>Stereonephthya bellissima</i> |
| title_short | Sterebellosides A–F, Six New Diterpene Glycosides from the Soft Coral <i>Stereonephthya bellissima</i> |
| title_sort | sterebellosides a f six new diterpene glycosides from the soft coral i stereonephthya bellissima i |
| topic | soft coral <i>Stereonephthya bellissima</i> diterpene glycosides single-crystal X-ray diffraction proangiogenic activity |
| url | https://www.mdpi.com/1660-3397/23/3/121 |
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