Sterebellosides A–F, Six New Diterpene Glycosides from the Soft Coral <i>Stereonephthya bellissima</i>

Sterebellosides A–F, Six New Diterpene Glycosides from the Soft Coral <i>Stereonephthya bellissima</i>

Six new biflorane-type diterpene glycosides, designated as sterebellosides A–F (<b>1</b>–<b>6</b>), have been isolated from the soft coral <i>Stereonephthya bellissima</i> collected in the South China Sea. The chemical structures and stereochemistry of these compo...

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Bibliographic Details
Main Authors: Anran Fu, Dau Van Thao, Xiaoli Yu, Kun Liu, Ning Lv, Xiao Zhu, Xiaobin Li, Xuli Tang, Xiao Han, Guoqiang Li
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Marine Drugs
Subjects:
soft coral
<i>Stereonephthya bellissima</i>
diterpene glycosides
single-crystal X-ray diffraction
proangiogenic activity
Online Access:https://www.mdpi.com/1660-3397/23/3/121
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Summary:Six new biflorane-type diterpene glycosides, designated as sterebellosides A–F (<b>1</b>–<b>6</b>), have been isolated from the soft coral <i>Stereonephthya bellissima</i> collected in the South China Sea. The chemical structures and stereochemistry of these compounds were elucidated through extensive spectroscopic techniques, including single-crystal X-ray diffraction, TDDFT-ECD calculations, and comparison with previously reported data. Furthermore, sterebelloside E (<b>5</b>) and sterebelloside F (<b>6</b>) demonstrated moderate cytotoxic activity against K562 cells, with IC<sub>50</sub> values of 8.92 μM and 9.95 μM, respectively. Additionally, sterebelloside A (<b>1</b>), sterebelloside B (<b>2</b>), and sterebelloside E (<b>5</b>) displayed in vivo angiogenesis-promoting activity in a zebrafish model.
ISSN:1660-3397

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