miR-155 Promotes ox-LDL-Induced Autophagy in Human Umbilical Vein Endothelial Cells
As an evolutionarily conserved metabolic process, autophagy is involved in the process of atherosclerosis (AS). MicroRNA-155 (miR-155), a multifunctional miRNA, plays an important role in many physiological and pathological conditions, including AS and autophagy. However, the effect of miR-155 on th...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/9174801 |
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| author | Zhaozhi Zhang Xudong Pan Shaonan Yang Aijun Ma Kun Wang Yuan Wang Ting Li Shihai Liu |
| author_facet | Zhaozhi Zhang Xudong Pan Shaonan Yang Aijun Ma Kun Wang Yuan Wang Ting Li Shihai Liu |
| author_sort | Zhaozhi Zhang |
| collection | DOAJ |
| description | As an evolutionarily conserved metabolic process, autophagy is involved in the process of atherosclerosis (AS). MicroRNA-155 (miR-155), a multifunctional miRNA, plays an important role in many physiological and pathological conditions, including AS and autophagy. However, the effect of miR-155 on the regulation of autophagy in endothelial cells has not been reported to date. Therefore, the objective of our study was to investigate the role of miR-155 in autophagy induced by oxidized low-density lipoprotein (ox-LDL) in human umbilical vein endothelial cells (HUVECs). Our results demonstrated that ox-LDL induced autophagy in HUVECs and increased the expression of miR-155 significantly. Overexpression of miR-155 improved autophagic activity, whereas low expression of miR-155 inhibited autophagic activity. Therefore, the data demonstrated that miR-155 has a modulating effect on the autophagy of vascular endothelial cells. |
| format | Article |
| id | doaj-art-bd2bbf465fcc4a9889e3b1764d93bfad |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-bd2bbf465fcc4a9889e3b1764d93bfad2025-08-20T02:18:54ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/91748019174801miR-155 Promotes ox-LDL-Induced Autophagy in Human Umbilical Vein Endothelial CellsZhaozhi Zhang0Xudong Pan1Shaonan Yang2Aijun Ma3Kun Wang4Yuan Wang5Ting Li6Shihai Liu7Department of Neurology, The Affiliated Hospital of the Qingdao University, Qingdao, Shandong 266100, ChinaDepartment of Neurology, The Affiliated Hospital of the Qingdao University, Qingdao, Shandong 266100, ChinaDepartment of Neurology, The Affiliated Hospital of the Qingdao University, Qingdao, Shandong 266100, ChinaDepartment of Neurology, The Affiliated Hospital of the Qingdao University, Qingdao, Shandong 266100, ChinaDepartment of Neurology, The Affiliated Hospital of the Qingdao University, Qingdao, Shandong 266100, ChinaDepartment of Neurology, The Affiliated Hospital of the Qingdao University, Qingdao, Shandong 266100, ChinaDepartment of Neurology, The Affiliated Hospital of the Qingdao University, Qingdao, Shandong 266100, ChinaCentral Laboratory, The Affiliated Hospital of the Qingdao University, Qingdao, Shandong 266100, ChinaAs an evolutionarily conserved metabolic process, autophagy is involved in the process of atherosclerosis (AS). MicroRNA-155 (miR-155), a multifunctional miRNA, plays an important role in many physiological and pathological conditions, including AS and autophagy. However, the effect of miR-155 on the regulation of autophagy in endothelial cells has not been reported to date. Therefore, the objective of our study was to investigate the role of miR-155 in autophagy induced by oxidized low-density lipoprotein (ox-LDL) in human umbilical vein endothelial cells (HUVECs). Our results demonstrated that ox-LDL induced autophagy in HUVECs and increased the expression of miR-155 significantly. Overexpression of miR-155 improved autophagic activity, whereas low expression of miR-155 inhibited autophagic activity. Therefore, the data demonstrated that miR-155 has a modulating effect on the autophagy of vascular endothelial cells.http://dx.doi.org/10.1155/2017/9174801 |
| spellingShingle | Zhaozhi Zhang Xudong Pan Shaonan Yang Aijun Ma Kun Wang Yuan Wang Ting Li Shihai Liu miR-155 Promotes ox-LDL-Induced Autophagy in Human Umbilical Vein Endothelial Cells Mediators of Inflammation |
| title | miR-155 Promotes ox-LDL-Induced Autophagy in Human Umbilical Vein Endothelial Cells |
| title_full | miR-155 Promotes ox-LDL-Induced Autophagy in Human Umbilical Vein Endothelial Cells |
| title_fullStr | miR-155 Promotes ox-LDL-Induced Autophagy in Human Umbilical Vein Endothelial Cells |
| title_full_unstemmed | miR-155 Promotes ox-LDL-Induced Autophagy in Human Umbilical Vein Endothelial Cells |
| title_short | miR-155 Promotes ox-LDL-Induced Autophagy in Human Umbilical Vein Endothelial Cells |
| title_sort | mir 155 promotes ox ldl induced autophagy in human umbilical vein endothelial cells |
| url | http://dx.doi.org/10.1155/2017/9174801 |
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