Ellagitannins and Their Derivatives: A Review on the Metabolization, Absorption, and Some Benefits Related to Intestinal Health
Ellagitannins are bioactive phenolic acids found in various fruits, plants, and beverages such as wine and spirits. This review aims to discuss the metabolism, absorption, and some health benefits related to the intestinal activity of these molecules, as well as some supplements developed from them....
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MDPI AG
2025-06-01
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| author | Erick M. Raya-Morquecho Pedro Aguilar-Zarate Leonardo Sepúlveda Mariela R. Michel Anna Iliná Cristóbal N. Aguilar Juan A. Ascacio-Valdés |
| author_facet | Erick M. Raya-Morquecho Pedro Aguilar-Zarate Leonardo Sepúlveda Mariela R. Michel Anna Iliná Cristóbal N. Aguilar Juan A. Ascacio-Valdés |
| author_sort | Erick M. Raya-Morquecho |
| collection | DOAJ |
| description | Ellagitannins are bioactive phenolic acids found in various fruits, plants, and beverages such as wine and spirits. This review aims to discuss the metabolism, absorption, and some health benefits related to the intestinal activity of these molecules, as well as some supplements developed from them. Ellagitannins are first biodegraded to ellagic acid and then to urolithins, which are more easily absorbed. This process is mediated by specific enzymes and intestinal microbiota. Not all individuals can metabolize ellagitannins into urolithins due to differences in the composition of the intestinal microbiota, resulting in three phenotypes: metabotypes A, B, and 0. In recent decades, ellagitannins and their derivatives (ellagic acid and urolithins) have gained significant attention for their potential benefits against various digestive diseases, including irritable bowel syndrome, peptic ulcers, gastritis, colon cancer, esophageal cancer, and pancreatic cancer. As a result, nutraceutical supplements have been developed to treat these conditions, representing significant and promising applications of these compounds in digestive health. |
| format | Article |
| id | doaj-art-bd27e703e2c040b5bf03898e3e90df0e |
| institution | OA Journals |
| issn | 2036-7481 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microbiology Research |
| spelling | doaj-art-bd27e703e2c040b5bf03898e3e90df0e2025-08-20T02:20:59ZengMDPI AGMicrobiology Research2036-74812025-06-0116611310.3390/microbiolres16060113Ellagitannins and Their Derivatives: A Review on the Metabolization, Absorption, and Some Benefits Related to Intestinal HealthErick M. Raya-Morquecho0Pedro Aguilar-Zarate1Leonardo Sepúlveda2Mariela R. Michel3Anna Iliná4Cristóbal N. Aguilar5Juan A. Ascacio-Valdés6Bioprocesses & Bioproducts Research Group, Food Research Department, School of Chemistry, Autonomous University of Coahuila, Saltillo 25280, MexicoLaboratorio Nacional CONAHCYT Para la Evaluación de Productos Bióticos-LaNAEPBi, Unidad de Servicio Tecnológico Nacional de México/I. T. de Ciudad Valles, San Luis Potosí 79010, MexicoBioprocesses & Bioproducts Research Group, Food Research Department, School of Chemistry, Autonomous University of Coahuila, Saltillo 25280, MexicoLaboratorio Nacional CONAHCYT Para la Evaluación de Productos Bióticos-LaNAEPBi, Unidad de Servicio Tecnológico Nacional de México/I. T. de Ciudad Valles, San Luis Potosí 79010, MexicoNanobioscience Group, Chemistry School, Autonomous University of Coahuila, Saltillo 25280, MexicoBioprocesses & Bioproducts Research Group, Food Research Department, School of Chemistry, Autonomous University of Coahuila, Saltillo 25280, MexicoBioprocesses & Bioproducts Research Group, Food Research Department, School of Chemistry, Autonomous University of Coahuila, Saltillo 25280, MexicoEllagitannins are bioactive phenolic acids found in various fruits, plants, and beverages such as wine and spirits. This review aims to discuss the metabolism, absorption, and some health benefits related to the intestinal activity of these molecules, as well as some supplements developed from them. Ellagitannins are first biodegraded to ellagic acid and then to urolithins, which are more easily absorbed. This process is mediated by specific enzymes and intestinal microbiota. Not all individuals can metabolize ellagitannins into urolithins due to differences in the composition of the intestinal microbiota, resulting in three phenotypes: metabotypes A, B, and 0. In recent decades, ellagitannins and their derivatives (ellagic acid and urolithins) have gained significant attention for their potential benefits against various digestive diseases, including irritable bowel syndrome, peptic ulcers, gastritis, colon cancer, esophageal cancer, and pancreatic cancer. As a result, nutraceutical supplements have been developed to treat these conditions, representing significant and promising applications of these compounds in digestive health.https://www.mdpi.com/2036-7481/16/6/113ellagitanninsellagic acidurolithinsintestinal absorptiondigestive diseases |
| spellingShingle | Erick M. Raya-Morquecho Pedro Aguilar-Zarate Leonardo Sepúlveda Mariela R. Michel Anna Iliná Cristóbal N. Aguilar Juan A. Ascacio-Valdés Ellagitannins and Their Derivatives: A Review on the Metabolization, Absorption, and Some Benefits Related to Intestinal Health Microbiology Research ellagitannins ellagic acid urolithins intestinal absorption digestive diseases |
| title | Ellagitannins and Their Derivatives: A Review on the Metabolization, Absorption, and Some Benefits Related to Intestinal Health |
| title_full | Ellagitannins and Their Derivatives: A Review on the Metabolization, Absorption, and Some Benefits Related to Intestinal Health |
| title_fullStr | Ellagitannins and Their Derivatives: A Review on the Metabolization, Absorption, and Some Benefits Related to Intestinal Health |
| title_full_unstemmed | Ellagitannins and Their Derivatives: A Review on the Metabolization, Absorption, and Some Benefits Related to Intestinal Health |
| title_short | Ellagitannins and Their Derivatives: A Review on the Metabolization, Absorption, and Some Benefits Related to Intestinal Health |
| title_sort | ellagitannins and their derivatives a review on the metabolization absorption and some benefits related to intestinal health |
| topic | ellagitannins ellagic acid urolithins intestinal absorption digestive diseases |
| url | https://www.mdpi.com/2036-7481/16/6/113 |
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