The relationship between lipids level and cerebral microbleeds in patients with spontaneous intracerebral hemorrhage
BackgroundPrevious studies indicate a potential link between elevated serum lipid levels and an increased risk of cerebral microbleeds (CMBs). Since multiple CMBs can elevate the risk of future intracerebral hemorrhage (ICH), it is important to explore the relationship between lipid profiles and CMB...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1619440/full |
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| author | Hao Feng Xin Wang Wenjuan Wang Xingquan Zhao Xingquan Zhao Xingquan Zhao Xingquan Zhao |
| author_facet | Hao Feng Xin Wang Wenjuan Wang Xingquan Zhao Xingquan Zhao Xingquan Zhao Xingquan Zhao |
| author_sort | Hao Feng |
| collection | DOAJ |
| description | BackgroundPrevious studies indicate a potential link between elevated serum lipid levels and an increased risk of cerebral microbleeds (CMBs). Since multiple CMBs can elevate the risk of future intracerebral hemorrhage (ICH), it is important to explore the relationship between lipid profiles and CMBs in ICH patients. However, data on this specific correlation in ICH populations are currently limited.MethodsThis study retrospectively enrolled 223 consecutive patients from a spontaneous ICH cohort. We collected comprehensive clinical, demographic, and laboratory data, with a focus on lipid levels and the presence of CMBs. Using a multivariate logistic regression model, we investigated the association between lipid parameters and CMB occurrence.ResultsAmong the 223 patients, 111 (49.8%) had CMBs. Univariate analysis showed that individuals without lobar CMBs tended to have higher levels of serum total cholesterol (TC), low-density lipoprotein (LDL), and non-high-density lipoprotein (Non-HDL). After adjusting for potential confounders, TC [odds ratio (OR), 0.989; 95% confidence interval (CI), 0.979–0.999; p = 0.028] and Non-HDL (OR, 0.989; 95% CI, 0.979–1.000; p = 0.043) were identified as independent predictors of lobar CMBs.ConclusionOur findings suggest an inverse correlation between TC and Non-HDL levels and the presence of lobar CMBs in ICH patients. Further prospective studies are needed to clarify the causal relationship between statin use and CMBs in ICH patients and to evaluate the prognostic significance of CMB presence and severity in statin-treated individuals. |
| format | Article |
| id | doaj-art-bd22c4be8a1e4b93a5aca1c60eb39b26 |
| institution | DOAJ |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-bd22c4be8a1e4b93a5aca1c60eb39b262025-08-20T03:12:43ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-07-011610.3389/fneur.2025.16194401619440The relationship between lipids level and cerebral microbleeds in patients with spontaneous intracerebral hemorrhageHao Feng0Xin Wang1Wenjuan Wang2Xingquan Zhao3Xingquan Zhao4Xingquan Zhao5Xingquan Zhao6Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke Beijing Institute for Brain Disorders, Beijing, ChinaResearch Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences, Beijing, ChinaBackgroundPrevious studies indicate a potential link between elevated serum lipid levels and an increased risk of cerebral microbleeds (CMBs). Since multiple CMBs can elevate the risk of future intracerebral hemorrhage (ICH), it is important to explore the relationship between lipid profiles and CMBs in ICH patients. However, data on this specific correlation in ICH populations are currently limited.MethodsThis study retrospectively enrolled 223 consecutive patients from a spontaneous ICH cohort. We collected comprehensive clinical, demographic, and laboratory data, with a focus on lipid levels and the presence of CMBs. Using a multivariate logistic regression model, we investigated the association between lipid parameters and CMB occurrence.ResultsAmong the 223 patients, 111 (49.8%) had CMBs. Univariate analysis showed that individuals without lobar CMBs tended to have higher levels of serum total cholesterol (TC), low-density lipoprotein (LDL), and non-high-density lipoprotein (Non-HDL). After adjusting for potential confounders, TC [odds ratio (OR), 0.989; 95% confidence interval (CI), 0.979–0.999; p = 0.028] and Non-HDL (OR, 0.989; 95% CI, 0.979–1.000; p = 0.043) were identified as independent predictors of lobar CMBs.ConclusionOur findings suggest an inverse correlation between TC and Non-HDL levels and the presence of lobar CMBs in ICH patients. Further prospective studies are needed to clarify the causal relationship between statin use and CMBs in ICH patients and to evaluate the prognostic significance of CMB presence and severity in statin-treated individuals.https://www.frontiersin.org/articles/10.3389/fneur.2025.1619440/fullspontaneousintracerebral hemorrhagetotal cholesterolnon-high-density lipoproteincerebral microbleeds |
| spellingShingle | Hao Feng Xin Wang Wenjuan Wang Xingquan Zhao Xingquan Zhao Xingquan Zhao Xingquan Zhao The relationship between lipids level and cerebral microbleeds in patients with spontaneous intracerebral hemorrhage Frontiers in Neurology spontaneous intracerebral hemorrhage total cholesterol non-high-density lipoprotein cerebral microbleeds |
| title | The relationship between lipids level and cerebral microbleeds in patients with spontaneous intracerebral hemorrhage |
| title_full | The relationship between lipids level and cerebral microbleeds in patients with spontaneous intracerebral hemorrhage |
| title_fullStr | The relationship between lipids level and cerebral microbleeds in patients with spontaneous intracerebral hemorrhage |
| title_full_unstemmed | The relationship between lipids level and cerebral microbleeds in patients with spontaneous intracerebral hemorrhage |
| title_short | The relationship between lipids level and cerebral microbleeds in patients with spontaneous intracerebral hemorrhage |
| title_sort | relationship between lipids level and cerebral microbleeds in patients with spontaneous intracerebral hemorrhage |
| topic | spontaneous intracerebral hemorrhage total cholesterol non-high-density lipoprotein cerebral microbleeds |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1619440/full |
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