Role of cell-based therapies in digestive disorders: Obstacles and opportunities
Stem cell-based therapies have emerged as a promising frontier in the treatment of gastrointestinal disorders, offering potential solutions for challenges posed by conventional treatments. This review comprehensively examines recent advancements in cell-based therapeutic strategies, particularly foc...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Regenerative Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320425000355 |
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| author | Guodong Liang Yuehan Ma Ping Deng Shufeng Li Chunyan He Haihang He Hairui Liu Yunda Fan Ze Li |
| author_facet | Guodong Liang Yuehan Ma Ping Deng Shufeng Li Chunyan He Haihang He Hairui Liu Yunda Fan Ze Li |
| author_sort | Guodong Liang |
| collection | DOAJ |
| description | Stem cell-based therapies have emerged as a promising frontier in the treatment of gastrointestinal disorders, offering potential solutions for challenges posed by conventional treatments. This review comprehensively examines recent advancements in cell-based therapeutic strategies, particularly focusing on stem cell applications, immunotherapy, and cellular therapies for digestive diseases. It highlights the successful differentiation of enteric neural progenitors from pluripotent stem cells and their application in animal models, such as Hirschsprung disease. Furthermore, the review evaluates clinical trials and experimental studies demonstrating the potential of stem cells in regenerating damaged tissues, modulating immune responses, and promoting healing in conditions like Crohn's disease and liver failure. By addressing challenges, such as scalability, immunogenicity, and ethical considerations, the review underscores the translational opportunities and obstacles in realizing the clinical potential of these therapies. Concluding with an emphasis on future directions, the study provides insights into optimizing therapeutic efficacy and fostering innovations in personalized medicine for digestive disorders. |
| format | Article |
| id | doaj-art-bd1ddfa4a13347308ee1c6f104e0df9b |
| institution | Kabale University |
| issn | 2352-3204 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj-art-bd1ddfa4a13347308ee1c6f104e0df9b2025-08-20T03:53:12ZengElsevierRegenerative Therapy2352-32042025-06-012911810.1016/j.reth.2025.02.009Role of cell-based therapies in digestive disorders: Obstacles and opportunitiesGuodong Liang0Yuehan Ma1Ping Deng2Shufeng Li3Chunyan He4Haihang He5Hairui Liu6Yunda Fan7Ze Li8First Surgery Department of Colorectal, Gastric and Abdominal Tumors, Jilin Cancer Hospital, Changchun 130012, ChinaFirst Surgery Department of Colorectal, Gastric and Abdominal Tumors, Jilin Cancer Hospital, Changchun 130012, ChinaMedical Department, Jilin Cancer Hospital, Changchun 130012, ChinaFirst Department of Gynecological Tumor, Jilin Cancer Hospital, Changchun 130012, China; Corresponding author.Department of Anaesthesia, Jilin Cancer Hospital, Changchun 130012, ChinaDepartment of Otorhinolaryngology, Oral Maxillofacial, Head and Neck, Jilin Cancer Hospital, Changchun 130012, ChinaFirst Surgery Department of Colorectal, Gastric and Abdominal Tumors, Jilin Cancer Hospital, Changchun 130012, ChinaFirst Surgery Department of Colorectal, Gastric and Abdominal Tumors, Jilin Cancer Hospital, Changchun 130012, ChinaFirst Surgery Department of Colorectal, Gastric and Abdominal Tumors, Jilin Cancer Hospital, Changchun 130012, ChinaStem cell-based therapies have emerged as a promising frontier in the treatment of gastrointestinal disorders, offering potential solutions for challenges posed by conventional treatments. This review comprehensively examines recent advancements in cell-based therapeutic strategies, particularly focusing on stem cell applications, immunotherapy, and cellular therapies for digestive diseases. It highlights the successful differentiation of enteric neural progenitors from pluripotent stem cells and their application in animal models, such as Hirschsprung disease. Furthermore, the review evaluates clinical trials and experimental studies demonstrating the potential of stem cells in regenerating damaged tissues, modulating immune responses, and promoting healing in conditions like Crohn's disease and liver failure. By addressing challenges, such as scalability, immunogenicity, and ethical considerations, the review underscores the translational opportunities and obstacles in realizing the clinical potential of these therapies. Concluding with an emphasis on future directions, the study provides insights into optimizing therapeutic efficacy and fostering innovations in personalized medicine for digestive disorders.http://www.sciencedirect.com/science/article/pii/S2352320425000355Cellular therapiesStem cellsGastrointestinal disease |
| spellingShingle | Guodong Liang Yuehan Ma Ping Deng Shufeng Li Chunyan He Haihang He Hairui Liu Yunda Fan Ze Li Role of cell-based therapies in digestive disorders: Obstacles and opportunities Regenerative Therapy Cellular therapies Stem cells Gastrointestinal disease |
| title | Role of cell-based therapies in digestive disorders: Obstacles and opportunities |
| title_full | Role of cell-based therapies in digestive disorders: Obstacles and opportunities |
| title_fullStr | Role of cell-based therapies in digestive disorders: Obstacles and opportunities |
| title_full_unstemmed | Role of cell-based therapies in digestive disorders: Obstacles and opportunities |
| title_short | Role of cell-based therapies in digestive disorders: Obstacles and opportunities |
| title_sort | role of cell based therapies in digestive disorders obstacles and opportunities |
| topic | Cellular therapies Stem cells Gastrointestinal disease |
| url | http://www.sciencedirect.com/science/article/pii/S2352320425000355 |
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