In vitro and in-vivo exploration of physostigmine analogues to understand the mechanistic crosstalk between Klotho and targets for epilepsy

In vitro and in-vivo exploration of physostigmine analogues to understand the mechanistic crosstalk between Klotho and targets for epilepsy

BackgroundEpilepsy and seizures are characterized by neuronal hyperexcitability and damage, influenced by metabolic dysregulation, neuroinflammation, and oxidative stress. Despite available treatments, many patients remain resistant to therapy, necessitating novel therapeutic strategies. Klotho, a n...

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Bibliographic Details
Main Authors: Mansi Dahalia, Haya Majid, Mohd Junaid Khan, Akshat Rathi, Mohd Ashif Khan, Imran Ahmd Khan, Mohammed Samim, Sayeed Ur Rehman, Md Salik Noorani, Divya Vohora, Nidhi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
epilepsy
Klotho
physostigmine analogues
neuroinflammation
apoptosis
neuroprotection
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1580943/full
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