Viral mitochondriopathy in COVID-19
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), disrupts cellular mitochondria, leading to widespread chronic inflammation and multi-organ dysfunction. Viral proteins cause mitochondrial bioenergetic collapse, disrupt mitochondrial dyna...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Redox Biology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231725002794 |
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| author | Tsung-Hsien Chen Tien-Hsin Jeng Ming-Yang Lee Hsiang-Chen Wang Kun-Feng Tsai Chu-Kuang Chou |
| author_facet | Tsung-Hsien Chen Tien-Hsin Jeng Ming-Yang Lee Hsiang-Chen Wang Kun-Feng Tsai Chu-Kuang Chou |
| author_sort | Tsung-Hsien Chen |
| collection | DOAJ |
| description | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), disrupts cellular mitochondria, leading to widespread chronic inflammation and multi-organ dysfunction. Viral proteins cause mitochondrial bioenergetic collapse, disrupt mitochondrial dynamics, and impair ionic homeostasis, while avoiding antiviral defenses, including mitochondrial antiviral signaling. These changes drive both acute COVID-19 and its longer-term effects, known as “long COVID”. This review examines new findings on the mechanisms by which SARS-CoV-2 affects mitochondria and for the impact on chronic immunity, long-term health risks, and potential treatments. |
| format | Article |
| id | doaj-art-bd15c7f9243249b4b61a68a807e985e4 |
| institution | Kabale University |
| issn | 2213-2317 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj-art-bd15c7f9243249b4b61a68a807e985e42025-08-24T05:12:35ZengElsevierRedox Biology2213-23172025-09-018510376610.1016/j.redox.2025.103766Viral mitochondriopathy in COVID-19Tsung-Hsien Chen0Tien-Hsin Jeng1Ming-Yang Lee2Hsiang-Chen Wang3Kun-Feng Tsai4Chu-Kuang Chou5Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, 60002, TaiwanDivision of Pulmonary Medicine, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, 60002, TaiwanDivision of Hemato-Oncology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, 60002, Taiwan; Min-Hwei Junior College of Health Care Management, Tainan, 73658, TaiwanDepartment of Mechanical Engineering, National Chung Cheng University, Min Hsiung, Chiayi, 62102, TaiwanDepartment of Internal Medicine, Gastroenterology and Hepatology Section, An Nan Hospital, China Medical University, Tainan, 70965, Taiwan; Department of Medical Sciences Industry, Chang Jung Christian University, Tainan, 71101, Taiwan; Corresponding author. Department of Internal Medicine, Gastroenterology and Hepatology Section, An Nan Hospital, China Medical University, 66, Section 2, Zhanghe Road, Tainan, 70965, Taiwan.Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, 60002, Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, 60002, Taiwan; Obesity center, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, 60002, Taiwan; Corresponding author. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian Hospital, 539 Jhongsiao Road, Chiayi, 60002, Taiwan.Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), disrupts cellular mitochondria, leading to widespread chronic inflammation and multi-organ dysfunction. Viral proteins cause mitochondrial bioenergetic collapse, disrupt mitochondrial dynamics, and impair ionic homeostasis, while avoiding antiviral defenses, including mitochondrial antiviral signaling. These changes drive both acute COVID-19 and its longer-term effects, known as “long COVID”. This review examines new findings on the mechanisms by which SARS-CoV-2 affects mitochondria and for the impact on chronic immunity, long-term health risks, and potential treatments.http://www.sciencedirect.com/science/article/pii/S2213231725002794SARS-CoV-2MitochondriaMitochondrial antiviral signaling pathwayLong COVIDChronic inflammationExacerbation |
| spellingShingle | Tsung-Hsien Chen Tien-Hsin Jeng Ming-Yang Lee Hsiang-Chen Wang Kun-Feng Tsai Chu-Kuang Chou Viral mitochondriopathy in COVID-19 Redox Biology SARS-CoV-2 Mitochondria Mitochondrial antiviral signaling pathway Long COVID Chronic inflammation Exacerbation |
| title | Viral mitochondriopathy in COVID-19 |
| title_full | Viral mitochondriopathy in COVID-19 |
| title_fullStr | Viral mitochondriopathy in COVID-19 |
| title_full_unstemmed | Viral mitochondriopathy in COVID-19 |
| title_short | Viral mitochondriopathy in COVID-19 |
| title_sort | viral mitochondriopathy in covid 19 |
| topic | SARS-CoV-2 Mitochondria Mitochondrial antiviral signaling pathway Long COVID Chronic inflammation Exacerbation |
| url | http://www.sciencedirect.com/science/article/pii/S2213231725002794 |
| work_keys_str_mv | AT tsunghsienchen viralmitochondriopathyincovid19 AT tienhsinjeng viralmitochondriopathyincovid19 AT mingyanglee viralmitochondriopathyincovid19 AT hsiangchenwang viralmitochondriopathyincovid19 AT kunfengtsai viralmitochondriopathyincovid19 AT chukuangchou viralmitochondriopathyincovid19 |