Value of three-dimensional speckle-tracking imaging in assessing left atrial function in patients with cirrhotic cardiomyopathy
Objective To investigate the value of three-dimensional speckle-tracking imaging (3D-STI) in assessing left atrial function in patients with cirrhotic cardiomyopathy (CCM). Methods A total of 165 patients with liver cirrhosis who were treated in The Affiliated Hospital of Qingdao University from Jan...
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of Journal of Precision Medicine
2025-08-01
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| Series: | 精准医学杂志 |
| Subjects: | |
| Online Access: | https://jpmed.qdu.edu.cn/fileup/2096-529X/PDF/1754471591331-1561719200.pdf |
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| Summary: | Objective To investigate the value of three-dimensional speckle-tracking imaging (3D-STI) in assessing left atrial function in patients with cirrhotic cardiomyopathy (CCM). Methods A total of 165 patients with liver cirrhosis who were treated in The Affiliated Hospital of Qingdao University from January 2021 to May 2024 were enrolled as cirrhosis group, and according to the presence or absence of cardiomyopathy, the patients were divided into CCM(+) group with 57 patients and CCM(-) group with 108 patients. In addition, 51 healthy individuals who underwent physical examination during the same period of time were enrolled as control group. Conventional echocardiography and 3D-STI were used to assess the left atrial structure and function of the subjects in each group, and the results were compared. Meanwhile, a multivariate logistic regression model was used to analyze the association between 3D-STI parameters and the onset of CCM in both CCM (+) and CCM (-) groups. Results Compared with the control group, the cirrhosis group had significant increases in LAD, late diastolic peak flow velocity (A), and mitral valve early diastolic peak flow velocity (E)/early diastolic mitral annular velocity (e') and significant reductions in e' and E/A (t=1.999-8.079,P<0.05), and there were no significant differences in these parameters between the CCM(+) group and the CCM(-) group (P>0.05). Compared with the control group, the liver cirrhosis group had significant reductions in LA-GLS, LA-GRS, LA-GCS, and LAEF and significant increases in LAVmax, LAVImax, LAVmin, and LAVImin (t=4.666-19.286,P<0.05). Compared with the CCM(-) group, the CCM(+) group had significant reductions in LA-GLS, LA-GRS, LA-GCS, and LAEF and significant increases in LAVmax, LAVImax, LAVmin, and LAVImin (t=2.637-16.307,P<0.05). The multivariate logistic regression analysis showed that LA-GLS and LA-GRS were significantly associated with the onset of CCM (χ2=4.771,5.601,P<0.05). Conclusion Compared with conventional echocardiography, 3D-STI can provide more comprehensive data for left atrial volume measurement and functional assessment and help to achieve early detection of occult abnormal changes in the left atrium. The reductions in LA-GLS and LA-GRS may suggest potential abnormalities in left atrial structure and function and thus assist in the prediction and early diagnosis of CCM in clinical practice. |
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| ISSN: | 2096-529X |