Humanized monoacylglycerol acyltransferase 2 mice develop metabolic dysfunction-associated steatohepatitis

Humanized monoacylglycerol acyltransferase 2 mice develop metabolic dysfunction-associated steatohepatitis

Mice lacking monoacylglycerol acyltransferase 2 (mMGAT21) are resistant to diet-induced fatty liver, suggesting hMOGAT2 inhibition is a viable option for treating metabolic dysfunction-associated steatotic liver disease (MASLD)/metabolic dysfunction-associated steatohepatitis (MASH). We generated hu...

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Bibliographic Details
Main Authors: J. Jose Corbalan, Pranavi Jagadeesan, Karla K. Frietze, Rulaiha Taylor, Grace L. Gao, Grant Gallagher, Joseph T. Nickels, Jr.
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Journal of Lipid Research
Subjects:
lipids
MASH
MASLD
monoacylglycerol acyltransferase
bile acids
RNASeq
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227524002001
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