Effect of primary structural variation on cervid prion protein in flexibility, stability, and spontaneous misfolding propensity

Effect of primary structural variation on cervid prion protein in flexibility, stability, and spontaneous misfolding propensity

Protein misfolding is central to numerous neurodegenerative disorders, collectively known as proteinopathies, which include Alzheimer's disease, Parkinson's disease, and prion diseases, among others. In many cases, specific polymorphisms of the proteins associated with these diseases influ...

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Bibliographic Details
Main Authors: Carlos M. Díaz-Domínguez, Hasier Eraña, Francesca Peccati, Enric Vidal, Jorge M. Charco, Cristina Sampedro-Torres-Quevedo, Miguel A. Pérez-Castro, Nuria L. Lorenzo, Samanta Giler, Glenn C. Telling, Mariví Geijo, Jesús R. Requena, Gonzalo Jiménez-Osés, Joaquín Castilla
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neurobiology of Disease
Subjects:
CWD
Misfolding
Polymorphisms
Prion
Proteinopathy
Stability
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125002219
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