EGFR mutations in Indian lung cancer patients: clinical correlation and outcome to EGFR targeted therapy.
Screening for EGFR mutation is a key molecular test for management of lung cancer patients. Outcome of patients with mutation receiving EGFR tyrosine kinase inhibitor is known to be better across different ethnic populations. However, frequency of EGFR mutations and the clinical response in most oth...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061561&type=printable |
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| author | Vanita Noronha Kumar Prabhash Abhishek Thavamani Anuradha Chougule Nilendu Purandare Amit Joshi Rashmi Sharma Saral Desai Nirmala Jambekar Amit Dutt Rita Mulherkar |
| author_facet | Vanita Noronha Kumar Prabhash Abhishek Thavamani Anuradha Chougule Nilendu Purandare Amit Joshi Rashmi Sharma Saral Desai Nirmala Jambekar Amit Dutt Rita Mulherkar |
| author_sort | Vanita Noronha |
| collection | DOAJ |
| description | Screening for EGFR mutation is a key molecular test for management of lung cancer patients. Outcome of patients with mutation receiving EGFR tyrosine kinase inhibitor is known to be better across different ethnic populations. However, frequency of EGFR mutations and the clinical response in most other ethnic populations, including India, remains to be explored. We conducted a retrospective analysis of Indian lung cancer patients who were managed with oral tyrosine kinase inhibitors. Majority of the patients in the study had adenocarcinoma and were non-smokers. 39/111 patients tested positive for EGFR kinase domain mutations determined by Taqman based real time PCR. The overall response to oral TKI therapy was 30%. Patients with an activating mutation of EGFR had a response rate of 74%, while the response rate in patients with wild type EGFR was 5%, which was a statistically significant difference. Progression free survival of patients with EGFR mutations was 10 months compared to 2 months for EGFR mutation negative patients. Overall survival was 19 months for EGFR mutation patients and 13 months for mutation negative patients. This study emphasizes EGFR mutation as an important predictive marker for response to oral tyrosine kinase inhibitors in the Indian population. |
| format | Article |
| id | doaj-art-bd0ce1015f484899be75e9565e85bbde |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-bd0ce1015f484899be75e9565e85bbde2025-08-20T03:09:47ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0184e6156110.1371/journal.pone.0061561EGFR mutations in Indian lung cancer patients: clinical correlation and outcome to EGFR targeted therapy.Vanita NoronhaKumar PrabhashAbhishek ThavamaniAnuradha ChouguleNilendu PurandareAmit JoshiRashmi SharmaSaral DesaiNirmala JambekarAmit DuttRita MulherkarScreening for EGFR mutation is a key molecular test for management of lung cancer patients. Outcome of patients with mutation receiving EGFR tyrosine kinase inhibitor is known to be better across different ethnic populations. However, frequency of EGFR mutations and the clinical response in most other ethnic populations, including India, remains to be explored. We conducted a retrospective analysis of Indian lung cancer patients who were managed with oral tyrosine kinase inhibitors. Majority of the patients in the study had adenocarcinoma and were non-smokers. 39/111 patients tested positive for EGFR kinase domain mutations determined by Taqman based real time PCR. The overall response to oral TKI therapy was 30%. Patients with an activating mutation of EGFR had a response rate of 74%, while the response rate in patients with wild type EGFR was 5%, which was a statistically significant difference. Progression free survival of patients with EGFR mutations was 10 months compared to 2 months for EGFR mutation negative patients. Overall survival was 19 months for EGFR mutation patients and 13 months for mutation negative patients. This study emphasizes EGFR mutation as an important predictive marker for response to oral tyrosine kinase inhibitors in the Indian population.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061561&type=printable |
| spellingShingle | Vanita Noronha Kumar Prabhash Abhishek Thavamani Anuradha Chougule Nilendu Purandare Amit Joshi Rashmi Sharma Saral Desai Nirmala Jambekar Amit Dutt Rita Mulherkar EGFR mutations in Indian lung cancer patients: clinical correlation and outcome to EGFR targeted therapy. PLoS ONE |
| title | EGFR mutations in Indian lung cancer patients: clinical correlation and outcome to EGFR targeted therapy. |
| title_full | EGFR mutations in Indian lung cancer patients: clinical correlation and outcome to EGFR targeted therapy. |
| title_fullStr | EGFR mutations in Indian lung cancer patients: clinical correlation and outcome to EGFR targeted therapy. |
| title_full_unstemmed | EGFR mutations in Indian lung cancer patients: clinical correlation and outcome to EGFR targeted therapy. |
| title_short | EGFR mutations in Indian lung cancer patients: clinical correlation and outcome to EGFR targeted therapy. |
| title_sort | egfr mutations in indian lung cancer patients clinical correlation and outcome to egfr targeted therapy |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061561&type=printable |
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