Investigation of Delefilcon A Contact Lenses for Symptomatic Daily Disposable Contact Lens Wearers with Dry Eye Disease: A Prospective Comparative Study
Sarah E Guthrie, Doerte Luensmann, Marc-Matthias Schulze, Jill Woods, Lyndon Jones Centre for Ocular Research & Education (CORE), School of Optometry & Vision Science, University of Waterloo, Waterloo, Ontario, N2L 3G1, CanadaCorrespondence: Sarah E Guthrie, Centre for Ocular Research &...
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Dove Medical Press
2024-10-01
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| Series: | Clinical Ophthalmology |
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| author | Guthrie SE Luensmann D Schulze MM Woods J Jones L |
| author_facet | Guthrie SE Luensmann D Schulze MM Woods J Jones L |
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| description | Sarah E Guthrie, Doerte Luensmann, Marc-Matthias Schulze, Jill Woods, Lyndon Jones Centre for Ocular Research & Education (CORE), School of Optometry & Vision Science, University of Waterloo, Waterloo, Ontario, N2L 3G1, CanadaCorrespondence: Sarah E Guthrie, Centre for Ocular Research & Education (CORE), School of Optometry & Vision Science, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada, Tel +1 519 888 4567, Fax +1 519 888 4303, Email sarah.guthrie@uwaterloo.caPurpose: This prospective comparative study aimed to assess the effects on contact lens comfort, dryness, and wear time when symptomatic daily disposable (DD) contact lens (CL) wearers were refit with delefilcon A (DT1) lenses.Patients and Methods: Thirty five symptomatic DD CL wearers with dry eye disease as determined according to the TFOS DEWS 2 guidelines, were enrolled and completed the study. Participants wore their habitual DD CLs during an initial assessment and were subsequently refit with DT1 for 1 month. Participants were masked to the study lens type. Subjective ratings of end-of-day comfort and dryness, average wear time, and comfortable wear time were evaluated as primary endpoints.Results: Of the 35 participants, two participants were classified as aqueous deficient dry eye, while the remaining participants exhibited symptoms primarily due to evaporative causes. The median CLDEQ-8 score for dryness significantly improved from 17 (fair) with habitual lenses to 13 (good) with DT1 lenses (p < 0.01). Participants reported significantly better end-of-day comfort (p = 0.01) and less end-of-day dryness (p = 0.01) with DT1 compared to their habitual DD lenses. The comfortable wear time was significantly longer with DT1 (8.5 ± 4.1 hours) compared to habitual DD lenses (6.7 ± 3.2 hours) (p = 0.04). No significant differences were observed in vision ratings (p = 0.07).Conclusion: Refitting symptomatic DD CL wearers with DT1 resulted in improved end-of-day comfort, reduced end-of-day dryness, and extended comfortable wear time compared to their habitual lenses. These findings suggest that DT1 may offer benefits for symptomatic DD wearers with dry eye disease.Keywords: contact lenses, daily disposable, delefilcon A, dry eye symptoms, comfort, wear time |
| format | Article |
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| language | English |
| publishDate | 2024-10-01 |
| publisher | Dove Medical Press |
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| series | Clinical Ophthalmology |
| spelling | doaj-art-bd0984751e2c4ff58377f0914ac76c8a2025-08-20T02:09:52ZengDove Medical PressClinical Ophthalmology1177-54832024-10-01Volume 182999300896590Investigation of Delefilcon A Contact Lenses for Symptomatic Daily Disposable Contact Lens Wearers with Dry Eye Disease: A Prospective Comparative StudyGuthrie SELuensmann DSchulze MMWoods JJones LSarah E Guthrie, Doerte Luensmann, Marc-Matthias Schulze, Jill Woods, Lyndon Jones Centre for Ocular Research & Education (CORE), School of Optometry & Vision Science, University of Waterloo, Waterloo, Ontario, N2L 3G1, CanadaCorrespondence: Sarah E Guthrie, Centre for Ocular Research & Education (CORE), School of Optometry & Vision Science, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada, Tel +1 519 888 4567, Fax +1 519 888 4303, Email sarah.guthrie@uwaterloo.caPurpose: This prospective comparative study aimed to assess the effects on contact lens comfort, dryness, and wear time when symptomatic daily disposable (DD) contact lens (CL) wearers were refit with delefilcon A (DT1) lenses.Patients and Methods: Thirty five symptomatic DD CL wearers with dry eye disease as determined according to the TFOS DEWS 2 guidelines, were enrolled and completed the study. Participants wore their habitual DD CLs during an initial assessment and were subsequently refit with DT1 for 1 month. Participants were masked to the study lens type. Subjective ratings of end-of-day comfort and dryness, average wear time, and comfortable wear time were evaluated as primary endpoints.Results: Of the 35 participants, two participants were classified as aqueous deficient dry eye, while the remaining participants exhibited symptoms primarily due to evaporative causes. The median CLDEQ-8 score for dryness significantly improved from 17 (fair) with habitual lenses to 13 (good) with DT1 lenses (p < 0.01). Participants reported significantly better end-of-day comfort (p = 0.01) and less end-of-day dryness (p = 0.01) with DT1 compared to their habitual DD lenses. The comfortable wear time was significantly longer with DT1 (8.5 ± 4.1 hours) compared to habitual DD lenses (6.7 ± 3.2 hours) (p = 0.04). No significant differences were observed in vision ratings (p = 0.07).Conclusion: Refitting symptomatic DD CL wearers with DT1 resulted in improved end-of-day comfort, reduced end-of-day dryness, and extended comfortable wear time compared to their habitual lenses. These findings suggest that DT1 may offer benefits for symptomatic DD wearers with dry eye disease.Keywords: contact lenses, daily disposable, delefilcon A, dry eye symptoms, comfort, wear timehttps://www.dovepress.com/investigation-of-delefilcon-a-contact-lenses-for-symptomatic-daily-dis-peer-reviewed-fulltext-article-OPTHcontact lensesdaily disposabledelefilcon adry eye symptomscomfortwear time |
| spellingShingle | Guthrie SE Luensmann D Schulze MM Woods J Jones L Investigation of Delefilcon A Contact Lenses for Symptomatic Daily Disposable Contact Lens Wearers with Dry Eye Disease: A Prospective Comparative Study Clinical Ophthalmology contact lenses daily disposable delefilcon a dry eye symptoms comfort wear time |
| title | Investigation of Delefilcon A Contact Lenses for Symptomatic Daily Disposable Contact Lens Wearers with Dry Eye Disease: A Prospective Comparative Study |
| title_full | Investigation of Delefilcon A Contact Lenses for Symptomatic Daily Disposable Contact Lens Wearers with Dry Eye Disease: A Prospective Comparative Study |
| title_fullStr | Investigation of Delefilcon A Contact Lenses for Symptomatic Daily Disposable Contact Lens Wearers with Dry Eye Disease: A Prospective Comparative Study |
| title_full_unstemmed | Investigation of Delefilcon A Contact Lenses for Symptomatic Daily Disposable Contact Lens Wearers with Dry Eye Disease: A Prospective Comparative Study |
| title_short | Investigation of Delefilcon A Contact Lenses for Symptomatic Daily Disposable Contact Lens Wearers with Dry Eye Disease: A Prospective Comparative Study |
| title_sort | investigation of delefilcon a contact lenses for symptomatic daily disposable contact lens wearers with dry eye disease a prospective comparative study |
| topic | contact lenses daily disposable delefilcon a dry eye symptoms comfort wear time |
| url | https://www.dovepress.com/investigation-of-delefilcon-a-contact-lenses-for-symptomatic-daily-dis-peer-reviewed-fulltext-article-OPTH |
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