Downregulation of CHIP promotes ovarian cancer metastasis by inducing Snail‐mediated epithelial–mesenchymal transition

Downregulation of CHIP promotes ovarian cancer metastasis by inducing Snail‐mediated epithelial–mesenchymal transition

The epithelial–mesenchymal transition (EMT) plays a pivotal role in the conversion of early‐stage tumors into invasive malignancies. The transcription factor Snail, an extremely unstable protein whose subcellular levels are regulated by many E3 ubiquitin ligases, promotes EMT as well as associated p...

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Bibliographic Details
Main Authors: Sun‐Mi Park, Seung‐Ho Park, Ki‐Jun Ryu, In‐Kyu Kim, Hyeontak Han, Hyo‐Jin Kim, Seon‐Hee Kim, Keun‐Seok Hong, Hyemin Kim, Minju Kim, Bok Im Cho, Jeong Doo Heo, Na Hyun Kim, Eun Mi Hwang, Jae‐Yong Park, Jong In Yook, Hee Jun Cho, Cheol Hwangbo, Kwang Dong Kim, Hoseok Song, Jiyun Yoo
Format: Article
Language:English
Published: Wiley 2019-05-01
Series:Molecular Oncology
Subjects:
cancer metastasis
CHIP
E3 ubiquitin ligase
EMT
ovarian cancer
snail
Online Access:https://doi.org/10.1002/1878-0261.12485
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