Splitting the chains: ultra-basal insulin analog uncovers a redox mechanism of hormone clearance
Reporting in Nature Communications, Kjeldsen and colleagues describe a redox mechanism of insulin clearance based on separation of A- and B chains. Exploiting an ultra-long-acting analog protected from classical clearance pathways, the study highlights principles of protein stability in pharmacology...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-54006-6 |
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| _version_ | 1850169331910967296 |
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| author | Michael A. Weiss |
| author_facet | Michael A. Weiss |
| author_sort | Michael A. Weiss |
| collection | DOAJ |
| description | Reporting in Nature Communications, Kjeldsen and colleagues describe a redox mechanism of insulin clearance based on separation of A- and B chains. Exploiting an ultra-long-acting analog protected from classical clearance pathways, the study highlights principles of protein stability in pharmacology. |
| format | Article |
| id | doaj-art-bd0527a919cc4b6690091d1ca32b1dec |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-bd0527a919cc4b6690091d1ca32b1dec2025-08-20T02:20:45ZengNature PortfolioNature Communications2041-17232024-11-011511310.1038/s41467-024-54006-6Splitting the chains: ultra-basal insulin analog uncovers a redox mechanism of hormone clearanceMichael A. Weiss0Department of Biochemistry & Molecular Biology, Indiana University School of MedicineReporting in Nature Communications, Kjeldsen and colleagues describe a redox mechanism of insulin clearance based on separation of A- and B chains. Exploiting an ultra-long-acting analog protected from classical clearance pathways, the study highlights principles of protein stability in pharmacology.https://doi.org/10.1038/s41467-024-54006-6 |
| spellingShingle | Michael A. Weiss Splitting the chains: ultra-basal insulin analog uncovers a redox mechanism of hormone clearance Nature Communications |
| title | Splitting the chains: ultra-basal insulin analog uncovers a redox mechanism of hormone clearance |
| title_full | Splitting the chains: ultra-basal insulin analog uncovers a redox mechanism of hormone clearance |
| title_fullStr | Splitting the chains: ultra-basal insulin analog uncovers a redox mechanism of hormone clearance |
| title_full_unstemmed | Splitting the chains: ultra-basal insulin analog uncovers a redox mechanism of hormone clearance |
| title_short | Splitting the chains: ultra-basal insulin analog uncovers a redox mechanism of hormone clearance |
| title_sort | splitting the chains ultra basal insulin analog uncovers a redox mechanism of hormone clearance |
| url | https://doi.org/10.1038/s41467-024-54006-6 |
| work_keys_str_mv | AT michaelaweiss splittingthechainsultrabasalinsulinanaloguncoversaredoxmechanismofhormoneclearance |