Licorice attenuates cisplatin-induced hepatotoxicity by alleviating endoplasmic reticulum stress and apoptosis

Licorice attenuates cisplatin-induced hepatotoxicity by alleviating endoplasmic reticulum stress and apoptosis

Cisplatin (CP), a widely used antineoplastic drug, could induce hepatotoxicity and is also one of the most common reasons for drug-induced liver injury (DILI). Licorice (Chinese name GanCao, GC) is a commonly used herbal drug in traditional Chinese medicine (TCM) that has been shown to treat liver d...

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Bibliographic Details
Main Authors: Jie Li, Xiujuan Yang, Xiaolong Lian, Baojian Li, Quhuan Ma, Lingling Yang, Guangmiao Gao, Yi Deng, Zhijun Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
licorice
hepatotoxicity
ER stress
PERK/ATF4/CHOP pathway
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1557125/full
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