Radiation therapy in clinically node positive HER2 positive breast cancer after primary systemic therapy and breast conserving surgery: pooled analysis of TRYPHAENA and NeoSphere trials

Radiation therapy in clinically node positive HER2 positive breast cancer after primary systemic therapy and breast conserving surgery: pooled analysis of TRYPHAENA and NeoSphere trials

Abstract Background The benefit of regional nodal irradiation (RNI) following modern primary systemic therapy (PST) in HER2-positive breast cancer (HER2 + BC) remains under investigation. The current study evaluates RNI practice patterns and outcomes based on the pathological response to PST in clin...

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Bibliographic Details
Main Authors: Mohamad El-Jammal, Omran Saifi, Jose Bazan, Youssef H. Zeidan
Format: Article
Language:English
Published: BMC 2025-06-01
Series:BMC Cancer
Subjects:
Radiation therapy
HER2-positive
Primary systemic therapy (PST)
Breast conservation
Pathological complete response (pCR)
Locoregional recurrence (LRR)
Online Access:https://doi.org/10.1186/s12885-025-14289-4
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