Distinct lipidomic profiles but similar improvements in aerobic capacity following sprint interval training versus moderate-intensity continuous training in male adolescents
BackgroundExercise-induced metabolic changes, especially lipidomic changes are generally associated with improvements in cardiovascular health. Despite numerous previous studies, the differences in lipidomic profile response to different types of exercise training remain unclear. This study aimed to...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2025.1475391/full |
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| author | Wantang Su Jianming Liu Jianming Liu Aozhe Wang Haifeng Zhang Yaqi Sun Zhiyi Yan Michael Svensson Ji-Guo Yu Li Zhao |
| author_facet | Wantang Su Jianming Liu Jianming Liu Aozhe Wang Haifeng Zhang Yaqi Sun Zhiyi Yan Michael Svensson Ji-Guo Yu Li Zhao |
| author_sort | Wantang Su |
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| description | BackgroundExercise-induced metabolic changes, especially lipidomic changes are generally associated with improvements in cardiovascular health. Despite numerous previous studies, the differences in lipidomic profile response to different types of exercise training remain unclear. This study aimed to investigate how two different exercise intensities affect aerobic capacity and serum lipidomic profiles in healthy adolescents.MethodsTwenty-four healthy untrained male adolescents (13.08 ± 0.88 years old) were recruited and randomly assigned to moderate-intensity continuous training (MICT) group or sprint interval training (SIT) group to complete a specific training on a cycle ergometer for 6 weeks. Peak oxygen uptake (VO2peak) and body composition were measured, and blood samples were collected for serum lipoproteins and lipidomic analysis. Anthropometric, VO2peak, and serum biochemical data were analyzed using two-way repeated analysis of variance, while targeted lipidomic analysis was performed by principal component analysis and paired-sample t-test.ResultsVO2peak significantly improved from 39.05 ± 8.17 to 47.52 ± 8.51 [F (1, 44) = 14.75, p < 0.05] for MICT and from 40.13 ± 6.37 to 48.42 ± 7.01 [F (1, 44) = 14.75, p < 0.05] for SIT. A total of 28 lipids in MICT and 5 lipids in SIT showed significant changes out of 276 identified lipids (FC > 1.5 or <1/1.5, FDR <0.05). In MICT, 21 lipids, including sphingolipid (SP) and phospholipid (PL), decreased, while 7 lipids increased. In SIT, all 5 lipids, which were free fatty acid (FFA), decreased.ConclusionAlthough both MICT and SIT induced similar and significant improvements in VO2peak, serum lipid adaptations to the training differed. The primary changes in serum lipidomic intermediates for both types of training were reductions; however, SIT affected FFA, while MICT predominantly influenced SPs and PLs. |
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| institution | Kabale University |
| issn | 1664-042X |
| language | English |
| publishDate | 2025-01-01 |
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| series | Frontiers in Physiology |
| spelling | doaj-art-bcf3cf741b8d42f395545ba36621e42b2025-01-30T06:22:47ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2025-01-011610.3389/fphys.2025.14753911475391Distinct lipidomic profiles but similar improvements in aerobic capacity following sprint interval training versus moderate-intensity continuous training in male adolescentsWantang Su0Jianming Liu1Jianming Liu2Aozhe Wang3Haifeng Zhang4Yaqi Sun5Zhiyi Yan6Michael Svensson7Ji-Guo Yu8Li Zhao9Department of Exercise Physiology, Beijing Sport University, Beijing, ChinaSchool of Competitive Sports, Beijing Sport University, Beijing, ChinaSchool of Physical Education and Sports Science, Qufu Normal University, Qufu, Shandong, ChinaDepartment of Exercise Physiology, Beijing Sport University, Beijing, ChinaBeijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, Beijing, ChinaDepartment of Exercise Physiology, Beijing Sport University, Beijing, ChinaDepartment of Exercise Physiology, Beijing Sport University, Beijing, ChinaDepartment of Community Medicine and Rehabilitation, Section of Sports Medicine, Umeå University, Umeå, SwedenDepartment of Community Medicine and Rehabilitation, Section of Sports Medicine, Umeå University, Umeå, SwedenDepartment of Exercise Physiology, Beijing Sport University, Beijing, ChinaBackgroundExercise-induced metabolic changes, especially lipidomic changes are generally associated with improvements in cardiovascular health. Despite numerous previous studies, the differences in lipidomic profile response to different types of exercise training remain unclear. This study aimed to investigate how two different exercise intensities affect aerobic capacity and serum lipidomic profiles in healthy adolescents.MethodsTwenty-four healthy untrained male adolescents (13.08 ± 0.88 years old) were recruited and randomly assigned to moderate-intensity continuous training (MICT) group or sprint interval training (SIT) group to complete a specific training on a cycle ergometer for 6 weeks. Peak oxygen uptake (VO2peak) and body composition were measured, and blood samples were collected for serum lipoproteins and lipidomic analysis. Anthropometric, VO2peak, and serum biochemical data were analyzed using two-way repeated analysis of variance, while targeted lipidomic analysis was performed by principal component analysis and paired-sample t-test.ResultsVO2peak significantly improved from 39.05 ± 8.17 to 47.52 ± 8.51 [F (1, 44) = 14.75, p < 0.05] for MICT and from 40.13 ± 6.37 to 48.42 ± 7.01 [F (1, 44) = 14.75, p < 0.05] for SIT. A total of 28 lipids in MICT and 5 lipids in SIT showed significant changes out of 276 identified lipids (FC > 1.5 or <1/1.5, FDR <0.05). In MICT, 21 lipids, including sphingolipid (SP) and phospholipid (PL), decreased, while 7 lipids increased. In SIT, all 5 lipids, which were free fatty acid (FFA), decreased.ConclusionAlthough both MICT and SIT induced similar and significant improvements in VO2peak, serum lipid adaptations to the training differed. The primary changes in serum lipidomic intermediates for both types of training were reductions; however, SIT affected FFA, while MICT predominantly influenced SPs and PLs.https://www.frontiersin.org/articles/10.3389/fphys.2025.1475391/fulllipidomicaerobic capacitymoderate-intensity continuous trainingsprint interval trainingadolescents |
| spellingShingle | Wantang Su Jianming Liu Jianming Liu Aozhe Wang Haifeng Zhang Yaqi Sun Zhiyi Yan Michael Svensson Ji-Guo Yu Li Zhao Distinct lipidomic profiles but similar improvements in aerobic capacity following sprint interval training versus moderate-intensity continuous training in male adolescents Frontiers in Physiology lipidomic aerobic capacity moderate-intensity continuous training sprint interval training adolescents |
| title | Distinct lipidomic profiles but similar improvements in aerobic capacity following sprint interval training versus moderate-intensity continuous training in male adolescents |
| title_full | Distinct lipidomic profiles but similar improvements in aerobic capacity following sprint interval training versus moderate-intensity continuous training in male adolescents |
| title_fullStr | Distinct lipidomic profiles but similar improvements in aerobic capacity following sprint interval training versus moderate-intensity continuous training in male adolescents |
| title_full_unstemmed | Distinct lipidomic profiles but similar improvements in aerobic capacity following sprint interval training versus moderate-intensity continuous training in male adolescents |
| title_short | Distinct lipidomic profiles but similar improvements in aerobic capacity following sprint interval training versus moderate-intensity continuous training in male adolescents |
| title_sort | distinct lipidomic profiles but similar improvements in aerobic capacity following sprint interval training versus moderate intensity continuous training in male adolescents |
| topic | lipidomic aerobic capacity moderate-intensity continuous training sprint interval training adolescents |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2025.1475391/full |
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