Alveolar epithelial cell dysfunction and epithelial-mesenchymal transition in pulmonary fibrosis pathogenesis

Alveolar epithelial cell dysfunction and epithelial-mesenchymal transition in pulmonary fibrosis pathogenesis

Pulmonary fibrosis (PF) is a progressive and lethal interstitial lung disease characterized by aberrant scar formation and destruction of alveolar architecture. Dysfunctional alveolar epithelial cells (AECs) play a central role in initiating PF, where chronic injury triggers apoptosis and disrupts e...

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Bibliographic Details
Main Authors: Caopei Zheng, Ling Zhang, Yuqing Sun, Yingmin Ma, Yulin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Molecular Biosciences
Subjects:
alveolar epithelial cell
epithelial-mesenchymal transition
molecular mechanisms
signaling pathways
pulmonary fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1564176/full
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