Exosomes derived from a mesenchymal-like endometrial regenerative cells ameliorate renal ischemia reperfusion injury through delivery of CD73

Exosomes derived from a mesenchymal-like endometrial regenerative cells ameliorate renal ischemia reperfusion injury through delivery of CD73

Abstract Background Renal ischemia reperfusion (I/R) injury is a major contributor to graft dysfunction and inflammation leading to graft loss. The deregulation of purinergic signaling has been implicated in the pathogenesis of renal I/R injury. CD73 and the generation of adenosine during purine met...

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Main Authors: Bo Shao, Hong-da Wang, Shao-hua Ren, Qiang Chen, Zhao-bo Wang, Yi-ni Xu, Tong Liu, Cheng-lu Sun, Yi-yi Xiao, Hong-yu Jiang, Yi-cheng Li, Peng-yu Zhao, Guang-mei Yang, Xu Liu, Yu-fan Ren, Hao Wang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Stem Cell Research & Therapy
Subjects:
Renal ischemia–reperfusion injury
CD73
Human endometrial regenerative cells
Exosome
Macrophage
Online Access:https://doi.org/10.1186/s13287-025-04275-9
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