Sensitive Determination of Hydrochlorothiazide Drug in the Various Samples Via Developed Method of CFIA System
Hydrochlorothiazide drug determination in pharmaceutical and biological urine samples using a novel continuous flow-injection analysis technique that is rapid, simple, economical, and sensitive. The complex formed by the reaction of hydrochlorothiazide and O-phenylenediamine with potassium ferricya...
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| Format: | Article |
| Language: | English |
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University of Baghdad, College of Science for Women
2024-09-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8460 |
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| author | Wasan A. Hanooan Bushra B. Qassim |
| author_facet | Wasan A. Hanooan Bushra B. Qassim |
| author_sort | Wasan A. Hanooan |
| collection | DOAJ |
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Hydrochlorothiazide drug determination in pharmaceutical and biological urine samples using a novel continuous flow-injection analysis technique that is rapid, simple, economical, and sensitive. The complex formed by the reaction of hydrochlorothiazide and O-phenylenediamine with potassium ferricyanide to produce an orange-colored product at 480 nm was the basis for the proposed method. Other chemical and physical parameters that affect the stability and development of the colored product used in this developed method includes sample volume, flow rate, reagent concentrations, and reaction coil. The proposed method’s linearity ranges from 5 to 150 μg.mL-1 and its correlation coefficients were 0.9988, and the recovery percentage and error percentage were 100.88 and 0.88, respectively. The detection limit and Limit of quantification values were 2.622 and 7.97. A sample throughput of 90 samples. hour1- . The new approach was effectively employed to determine the presence of hydrochlorothiazide in the pure, biological, and pharmaceutical samples.
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| format | Article |
| id | doaj-art-bcedba0ea557459ab290c1ea023b9b93 |
| institution | Kabale University |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-bcedba0ea557459ab290c1ea023b9b932025-08-20T03:36:03ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862024-09-0121910.21123/bsj.2024.8460Sensitive Determination of Hydrochlorothiazide Drug in the Various Samples Via Developed Method of CFIA System Wasan A. Hanooan0https://orcid.org/0009-0009-6982-8133Bushra B. Qassim1 Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq. & Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mustansiriyah, Baghdad, IraqDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Mustansiriyah, Baghdad, Iraq Hydrochlorothiazide drug determination in pharmaceutical and biological urine samples using a novel continuous flow-injection analysis technique that is rapid, simple, economical, and sensitive. The complex formed by the reaction of hydrochlorothiazide and O-phenylenediamine with potassium ferricyanide to produce an orange-colored product at 480 nm was the basis for the proposed method. Other chemical and physical parameters that affect the stability and development of the colored product used in this developed method includes sample volume, flow rate, reagent concentrations, and reaction coil. The proposed method’s linearity ranges from 5 to 150 μg.mL-1 and its correlation coefficients were 0.9988, and the recovery percentage and error percentage were 100.88 and 0.88, respectively. The detection limit and Limit of quantification values were 2.622 and 7.97. A sample throughput of 90 samples. hour1- . The new approach was effectively employed to determine the presence of hydrochlorothiazide in the pure, biological, and pharmaceutical samples. https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8460Biological samples, CFIA System, Hydrochlorothiazide, O-phenylenediamine, Pharmaceutical formulation |
| spellingShingle | Wasan A. Hanooan Bushra B. Qassim Sensitive Determination of Hydrochlorothiazide Drug in the Various Samples Via Developed Method of CFIA System مجلة بغداد للعلوم Biological samples, CFIA System, Hydrochlorothiazide, O-phenylenediamine, Pharmaceutical formulation |
| title | Sensitive Determination of Hydrochlorothiazide Drug in the Various Samples Via Developed Method of CFIA System |
| title_full | Sensitive Determination of Hydrochlorothiazide Drug in the Various Samples Via Developed Method of CFIA System |
| title_fullStr | Sensitive Determination of Hydrochlorothiazide Drug in the Various Samples Via Developed Method of CFIA System |
| title_full_unstemmed | Sensitive Determination of Hydrochlorothiazide Drug in the Various Samples Via Developed Method of CFIA System |
| title_short | Sensitive Determination of Hydrochlorothiazide Drug in the Various Samples Via Developed Method of CFIA System |
| title_sort | sensitive determination of hydrochlorothiazide drug in the various samples via developed method of cfia system |
| topic | Biological samples, CFIA System, Hydrochlorothiazide, O-phenylenediamine, Pharmaceutical formulation |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8460 |
| work_keys_str_mv | AT wasanahanooan sensitivedeterminationofhydrochlorothiazidedruginthevarioussamplesviadevelopedmethodofcfiasystem AT bushrabqassim sensitivedeterminationofhydrochlorothiazidedruginthevarioussamplesviadevelopedmethodofcfiasystem |