Cellulose-Based SERS Substrate for Vapor-Phase Thiol Detection with PCA for Enhanced Chemical Selectivity
In this work, we present a low-cost, label-free cellulose-based paper SERS (Surface-Enhanced Raman Scattering) substrate for the sensitive detection of thiol compounds. Uniform silver nanoparticles (AgNPs) were synthesized on cellulose filter paper via in situ reduction of a silver precursor under U...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-03-01
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| Series: | Chemosensors |
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| Online Access: | https://www.mdpi.com/2227-9040/13/3/101 |
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| author | Ba-Thong Trinh Sy Khiem Nguyen Dayeon Kim Huu-Quang Nguyen Jaebeom Lee Youngku Sohn Ilsun Yoon |
| author_facet | Ba-Thong Trinh Sy Khiem Nguyen Dayeon Kim Huu-Quang Nguyen Jaebeom Lee Youngku Sohn Ilsun Yoon |
| author_sort | Ba-Thong Trinh |
| collection | DOAJ |
| description | In this work, we present a low-cost, label-free cellulose-based paper SERS (Surface-Enhanced Raman Scattering) substrate for the sensitive detection of thiol compounds. Uniform silver nanoparticles (AgNPs) were synthesized on cellulose filter paper via in situ reduction of a silver precursor under UVC irradiation, achieving a high SERS enhancement factor of 8.5 × 10<sup>6</sup>. The Ag-cellulose substrate demonstrated reliable detection of benzenethiol, capturing its characteristic SERS signals with remarkable sensitivity. Quantitative analysis was enabled by adjusting exposure times for accurate calibration. Furthermore, Principal Component Analysis (PCA) was successfully employed to distinguish mixed samples of benzenethiol, hexanethiol, and propanethiol, showcasing the substrate’s capability in separating complex mixtures. This cellulose-based AgNP platform offers a sustainable, cost-effective solution for rapid chemical detection, with significant potential for real-world applications such as environmental monitoring and food safety. |
| format | Article |
| id | doaj-art-bcea739b8f1c49098cd8ecf758bdc519 |
| institution | OA Journals |
| issn | 2227-9040 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj-art-bcea739b8f1c49098cd8ecf758bdc5192025-08-20T02:11:09ZengMDPI AGChemosensors2227-90402025-03-0113310110.3390/chemosensors13030101Cellulose-Based SERS Substrate for Vapor-Phase Thiol Detection with PCA for Enhanced Chemical SelectivityBa-Thong Trinh0Sy Khiem Nguyen1Dayeon Kim2Huu-Quang Nguyen3Jaebeom Lee4Youngku Sohn5Ilsun Yoon6Department of Chemistry, Chungnam National University, Daejeon 34134, Republic of KoreaDepartment of Chemistry, Chungnam National University, Daejeon 34134, Republic of KoreaDepartment of Chemistry, Chungnam National University, Daejeon 34134, Republic of KoreaDepartment of Chemistry, Chungnam National University, Daejeon 34134, Republic of KoreaDepartment of Chemistry, Chungnam National University, Daejeon 34134, Republic of KoreaDepartment of Chemistry, Chungnam National University, Daejeon 34134, Republic of KoreaDepartment of Chemistry, Chungnam National University, Daejeon 34134, Republic of KoreaIn this work, we present a low-cost, label-free cellulose-based paper SERS (Surface-Enhanced Raman Scattering) substrate for the sensitive detection of thiol compounds. Uniform silver nanoparticles (AgNPs) were synthesized on cellulose filter paper via in situ reduction of a silver precursor under UVC irradiation, achieving a high SERS enhancement factor of 8.5 × 10<sup>6</sup>. The Ag-cellulose substrate demonstrated reliable detection of benzenethiol, capturing its characteristic SERS signals with remarkable sensitivity. Quantitative analysis was enabled by adjusting exposure times for accurate calibration. Furthermore, Principal Component Analysis (PCA) was successfully employed to distinguish mixed samples of benzenethiol, hexanethiol, and propanethiol, showcasing the substrate’s capability in separating complex mixtures. This cellulose-based AgNP platform offers a sustainable, cost-effective solution for rapid chemical detection, with significant potential for real-world applications such as environmental monitoring and food safety.https://www.mdpi.com/2227-9040/13/3/101paper-based SERS substratessilver nanoparticlevapor-phase detectionnanometer-scale gapsprincipal component analysis |
| spellingShingle | Ba-Thong Trinh Sy Khiem Nguyen Dayeon Kim Huu-Quang Nguyen Jaebeom Lee Youngku Sohn Ilsun Yoon Cellulose-Based SERS Substrate for Vapor-Phase Thiol Detection with PCA for Enhanced Chemical Selectivity Chemosensors paper-based SERS substrates silver nanoparticle vapor-phase detection nanometer-scale gaps principal component analysis |
| title | Cellulose-Based SERS Substrate for Vapor-Phase Thiol Detection with PCA for Enhanced Chemical Selectivity |
| title_full | Cellulose-Based SERS Substrate for Vapor-Phase Thiol Detection with PCA for Enhanced Chemical Selectivity |
| title_fullStr | Cellulose-Based SERS Substrate for Vapor-Phase Thiol Detection with PCA for Enhanced Chemical Selectivity |
| title_full_unstemmed | Cellulose-Based SERS Substrate for Vapor-Phase Thiol Detection with PCA for Enhanced Chemical Selectivity |
| title_short | Cellulose-Based SERS Substrate for Vapor-Phase Thiol Detection with PCA for Enhanced Chemical Selectivity |
| title_sort | cellulose based sers substrate for vapor phase thiol detection with pca for enhanced chemical selectivity |
| topic | paper-based SERS substrates silver nanoparticle vapor-phase detection nanometer-scale gaps principal component analysis |
| url | https://www.mdpi.com/2227-9040/13/3/101 |
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