Review of existing methodologies to assess the activity of CYP2D6 using exogenous and endogenous markers
Peculiarities of functioning and polymorphism of cytochrome P450 isoenzyme CYP2D6. Existing methods for determining its activity using endogenous markers. A review of studies on the screening of endogenous substrates, biotransformation mainly under the influence of isoenzyme CYP2D6. The results by d...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
LLC “Publisher OKI”
2014-04-01
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| Series: | Фармакокинетика и Фармакодинамика |
| Subjects: | |
| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/147 |
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| _version_ | 1849345146213105664 |
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| author | A. D. Abdrashitov G. N. Gildeeva G. V. Ramenskaya V. V. Smirnov |
| author_facet | A. D. Abdrashitov G. N. Gildeeva G. V. Ramenskaya V. V. Smirnov |
| author_sort | A. D. Abdrashitov |
| collection | DOAJ |
| description | Peculiarities of functioning and polymorphism of cytochrome P450 isoenzyme CYP2D6. Existing methods for determining its activity using endogenous markers. A review of studies on the screening of endogenous substrates, biotransformation mainly under the influence of isoenzyme CYP2D6. The results by determination pinoline relationship to its metabolite 6-hydroxy-1,2,3,4-tetrahydro-beta-carboline in vitro in cell culture and in vivo in mice for evaluation isoenzyme activity CYP2D6. |
| format | Article |
| id | doaj-art-bce9cc55c3dc44e78161ba07eec4caa5 |
| institution | Kabale University |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2014-04-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-bce9cc55c3dc44e78161ba07eec4caa52025-08-20T03:42:31ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302014-04-0101411146Review of existing methodologies to assess the activity of CYP2D6 using exogenous and endogenous markersA. D. Abdrashitov0G. N. Gildeeva1G. V. Ramenskaya2V. V. Smirnov3First Moscow State Medical University named after I.M. SechenovFirst Moscow State Medical University named after I.M. SechenovFirst Moscow State Medical University named after I.M. SechenovFirst Moscow State Medical University named after I.M. SechenovPeculiarities of functioning and polymorphism of cytochrome P450 isoenzyme CYP2D6. Existing methods for determining its activity using endogenous markers. A review of studies on the screening of endogenous substrates, biotransformation mainly under the influence of isoenzyme CYP2D6. The results by determination pinoline relationship to its metabolite 6-hydroxy-1,2,3,4-tetrahydro-beta-carboline in vitro in cell culture and in vivo in mice for evaluation isoenzyme activity CYP2D6.https://www.pharmacokinetica.ru/jour/article/view/147биотрансформациямежлекарственные взаимодействияфенотипированиеcyp2d6цитохром р450пинолинперсонализированная медицинаbiotransformationdrug interactionsphenotypingcyp2d6cytochrome p450pinolinepersonalized medicine |
| spellingShingle | A. D. Abdrashitov G. N. Gildeeva G. V. Ramenskaya V. V. Smirnov Review of existing methodologies to assess the activity of CYP2D6 using exogenous and endogenous markers Фармакокинетика и Фармакодинамика биотрансформация межлекарственные взаимодействия фенотипирование cyp2d6 цитохром р450 пинолин персонализированная медицина biotransformation drug interactions phenotyping cyp2d6 cytochrome p450 pinoline personalized medicine |
| title | Review of existing methodologies to assess the activity of CYP2D6 using exogenous and endogenous markers |
| title_full | Review of existing methodologies to assess the activity of CYP2D6 using exogenous and endogenous markers |
| title_fullStr | Review of existing methodologies to assess the activity of CYP2D6 using exogenous and endogenous markers |
| title_full_unstemmed | Review of existing methodologies to assess the activity of CYP2D6 using exogenous and endogenous markers |
| title_short | Review of existing methodologies to assess the activity of CYP2D6 using exogenous and endogenous markers |
| title_sort | review of existing methodologies to assess the activity of cyp2d6 using exogenous and endogenous markers |
| topic | биотрансформация межлекарственные взаимодействия фенотипирование cyp2d6 цитохром р450 пинолин персонализированная медицина biotransformation drug interactions phenotyping cyp2d6 cytochrome p450 pinoline personalized medicine |
| url | https://www.pharmacokinetica.ru/jour/article/view/147 |
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